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The archenemy of Sherlock Holmes, mastermind criminal, often considered the 'Napoleon of Crime'.

A brilliant psychiatrist and cannibalistic serial killer, adversary to FBI profiler, Will Graham, and later, Clarice Starling.

A con artist and serial killer who is talented in assuming the identities of his victims, he confronts various foes including private detectives or law enforcement figures.

The only woman to outwit Sherlock Holmes, regarded by him as 'THE woman'.

A highly skilled marksman and right-hand man of Professor Moriarty, he is a fierce opponent of Sherlock Holmes.

An evil genius who is the archenemy of British investigator Sir Denis Nayland Smith.

A mathematician and a criminal mastermind, he engages in a battle of wits with detective Sherlock Holmes.

Arch-nemesis of MI6 agent James Bond, founder and head of the criminal organization SPECTRE.

A mysterious and mythical crime lord whose very existence is debated, he becomes the focus in 'The Usual Suspects'.

Crime lord and adversary of James Bond in 'Live and Let Die', uses voodoo to instill fear.

An antihero and criminal who clashes with the authoritative Nurse Ratched in 'One Flew Over the Cuckoo's Nest'.

A teenage sociopath and the main antagonist in Graham Greene's 'Brighton Rock'.

Wealthy bullion dealer, skilled card cheat, and the main antagonist in the James Bond novel and film 'Goldfinger'.

A relentless police inspector who pursues the reformed criminal Jean Valjean over decades in Victor Hugo's 'Les Misérables'.

A manipulative and morally ambiguous figure, who Phillip Marlowe often encounters in Raymond Chandler's 'The Big Sleep'.

The evil alter ego of Dr. Jekyll who terrorizes London in Robert Louis Stevenson's 'Strange Case of Dr Jekyll and Mr Hyde'.

The primary antagonist in J.R.R. Tolkien's 'The Lord of the Rings', who manifests as the all-seeing eye.

The primary antagonist in Ken Kesey's 'One Flew Over the Cuckoo's Nest', she represents the oppressive force of institutional systems.

A mad scientist and member of SPECTRE with mechanical hands, fierce adversary of James Bond.

An antagonist in 'Through the Looking-Glass, and What Alice Found There' by Lewis Carroll, famous for her tyrannical and quick-tempered rule.

The pirate nemesis of Peter Pan in J.M. Barrie's play and novel, obsessed with vengeance.

A central character in the Star Wars universe, he is known for his black suit and deep breathing, opposing the Jedi.

The Dark Lord and archenemy of Harry Potter, he seeks to purify the wizarding world and achieve immortality.

The main antagonist in Alfred Hitchcock's 'Psycho', known for his severe mental illness and split personality.