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The main antagonist in Alfred Hitchcock's 'Psycho', known for his severe mental illness and split personality.

A mysterious and mythical crime lord whose very existence is debated, he becomes the focus in 'The Usual Suspects'.

An antihero and criminal who clashes with the authoritative Nurse Ratched in 'One Flew Over the Cuckoo's Nest'.

A central character in the Star Wars universe, he is known for his black suit and deep breathing, opposing the Jedi.

The primary antagonist in J.R.R. Tolkien's 'The Lord of the Rings', who manifests as the all-seeing eye.

A mad scientist and member of SPECTRE with mechanical hands, fierce adversary of James Bond.

A powerful mutant with the ability to manipulate magnetic fields, adversary of the X-Men, specifically his old friend Charles Xavier.

A highly skilled marksman and right-hand man of Professor Moriarty, he is a fierce opponent of Sherlock Holmes.

A manipulative and morally ambiguous figure, who Phillip Marlowe often encounters in Raymond Chandler's 'The Big Sleep'.

An antagonist in 'Through the Looking-Glass, and What Alice Found There' by Lewis Carroll, famous for her tyrannical and quick-tempered rule.

The archenemy of Sherlock Holmes, mastermind criminal, often considered the 'Napoleon of Crime'.

A mathematician and a criminal mastermind, he engages in a battle of wits with detective Sherlock Holmes.

A teenage sociopath and the main antagonist in Graham Greene's 'Brighton Rock'.

The evil alter ego of Dr. Jekyll who terrorizes London in Robert Louis Stevenson's 'Strange Case of Dr Jekyll and Mr Hyde'.

A brilliant psychiatrist and cannibalistic serial killer, adversary to FBI profiler, Will Graham, and later, Clarice Starling.

Arch-nemesis of MI6 agent James Bond, founder and head of the criminal organization SPECTRE.

Crime lord and adversary of James Bond in 'Live and Let Die', uses voodoo to instill fear.

A relentless police inspector who pursues the reformed criminal Jean Valjean over decades in Victor Hugo's 'Les Misérables'.

A con artist and serial killer who is talented in assuming the identities of his victims, he confronts various foes including private detectives or law enforcement figures.

The pirate nemesis of Peter Pan in J.M. Barrie's play and novel, obsessed with vengeance.

An evil genius who is the archenemy of British investigator Sir Denis Nayland Smith.

The only woman to outwit Sherlock Holmes, regarded by him as 'THE woman'.

The Dark Lord and archenemy of Harry Potter, he seeks to purify the wizarding world and achieve immortality.

Wealthy bullion dealer, skilled card cheat, and the main antagonist in the James Bond novel and film 'Goldfinger'.