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The only woman to outwit Sherlock Holmes, regarded by him as 'THE woman'.

An antihero and criminal who clashes with the authoritative Nurse Ratched in 'One Flew Over the Cuckoo's Nest'.

Wealthy bullion dealer, skilled card cheat, and the main antagonist in the James Bond novel and film 'Goldfinger'.

The pirate nemesis of Peter Pan in J.M. Barrie's play and novel, obsessed with vengeance.

An evil genius who is the archenemy of British investigator Sir Denis Nayland Smith.

Crime lord and adversary of James Bond in 'Live and Let Die', uses voodoo to instill fear.

A con artist and serial killer who is talented in assuming the identities of his victims, he confronts various foes including private detectives or law enforcement figures.

An antagonist in 'Through the Looking-Glass, and What Alice Found There' by Lewis Carroll, famous for her tyrannical and quick-tempered rule.

A central character in the Star Wars universe, he is known for his black suit and deep breathing, opposing the Jedi.

The main antagonist in Alfred Hitchcock's 'Psycho', known for his severe mental illness and split personality.

The Dark Lord and archenemy of Harry Potter, he seeks to purify the wizarding world and achieve immortality.

A brilliant psychiatrist and cannibalistic serial killer, adversary to FBI profiler, Will Graham, and later, Clarice Starling.

A highly skilled marksman and right-hand man of Professor Moriarty, he is a fierce opponent of Sherlock Holmes.

The primary antagonist in Ken Kesey's 'One Flew Over the Cuckoo's Nest', she represents the oppressive force of institutional systems.

Arch-nemesis of MI6 agent James Bond, founder and head of the criminal organization SPECTRE.

A manipulative and morally ambiguous figure, who Phillip Marlowe often encounters in Raymond Chandler's 'The Big Sleep'.

A mad scientist and member of SPECTRE with mechanical hands, fierce adversary of James Bond.

A powerful mutant with the ability to manipulate magnetic fields, adversary of the X-Men, specifically his old friend Charles Xavier.

A mathematician and a criminal mastermind, he engages in a battle of wits with detective Sherlock Holmes.

A mysterious and mythical crime lord whose very existence is debated, he becomes the focus in 'The Usual Suspects'.

A teenage sociopath and the main antagonist in Graham Greene's 'Brighton Rock'.

A relentless police inspector who pursues the reformed criminal Jean Valjean over decades in Victor Hugo's 'Les Misérables'.

The evil alter ego of Dr. Jekyll who terrorizes London in Robert Louis Stevenson's 'Strange Case of Dr Jekyll and Mr Hyde'.

The archenemy of Sherlock Holmes, mastermind criminal, often considered the 'Napoleon of Crime'.