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James Howlett, commonly known as Logan, possesses animal-keen senses, enhanced physical capabilities, and a healing factor. He was also subjected to the Weapon X program where his skeleton was bonded with adamantium. First appeared in The Incredible Hulk #180 (1974).

Blinded by a radioactive substance that fell from a truck, Matt Murdock gained radar sense and became the crime-fighting Daredevil. First appeared in Daredevil #1 (1964).

An android created by Ultron, Vision possesses the brain patterns of Wonder Man and a body made from synthetic materials. First appeared in The Avengers #57 (1968).

The Norse God of Thunder, sent to Earth by his father Odin as a punishment to learn humility. First appeared in Journey into Mystery #83 (1962).

Bitten by a radioactive spider during a high school experiment, Peter Parker gained spider-like abilities. First appeared in Amazing Fantasy #15 (1962).

Dr. Henry 'Hank' Pym discovered a size-altering substance called Pym Particles, allowing him to shrink or grow in scale. First appeared in Tales to Astonish #27 (1962).

Ororo Munroe discovered her mutant ability to control the weather when her parents died in Cairo. She was worshipped as a goddess before joining the X-Men. First appeared in Giant-Size X-Men #1 (1975).

Dr. Bruce Banner was caught in a gamma bomb explosion while trying to save a teenager. This turned him into the Hulk. First appeared in The Incredible Hulk #1 (1962).

Steve Rogers was a frail young man who was enhanced to the peak of human perfection by an experimental serum to aid the United States war effort. First appeared in Captain America Comics #1 (1941).

Captured by terrorists, billionaire industrialist Tony Stark created a powered suit of armor to escape. First appeared in Tales of Suspense #39 (1963).

Natasha Romanova (Romanoff) is a highly trained former KGB assassin who eventually becomes an agent of S.H.I.E.L.D. and a member of the Avengers. First appeared in Tales of Suspense #52 (1964).

Former neurosurgeon Dr. Stephen Strange becomes the Sorcerer Supreme after a car accident damages his hands and leads him to seek out a mystical healer. First appeared in Strange Tales #110 (1963).

Wanda Maximoff, born with the ability to alter reality in unspecific ways, is a powerful sorceress. First appeared in X-Men #4 (1964).

T'Challa is the king of the technologically advanced African nation of Wakanda, and gained his powers from the Wakandan Panther God. First appeared in Fantastic Four #52 (1966).