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In 'Return of the Jedi', the Battle of Endor involves the Rebel Alliance's ground assault on the shield generator and space battle against the second Death Star. Victory here leads to the fall of the Galactic Empire and redemption of a central character.

The finale of the Earth-Minbari War in 'Babylon 5', where humanity makes its last stand against the superior Minbari forces. The battle is significant for leading to an unexpected ceasefire and the eventual construction of the Babylon space stations.

In the anime series 'Robotech/Macross', this battle ends the first Robotech war against the Zentradi. It's a demonstration of the power of human culture and emotion to overcome seemingly insurmountable odds.

In 'The Avengers' (2012), the Battle of New York is the final confrontation between the Avengers and the Chitauri army, led by Loki. The battle is crucial as it not only saves Earth from invasion but also establishes the Avengers as a united team.

This is the opening conflict in 'Star Trek: Discovery', setting the stage for the Federation-Klingon war. The battle is significant for its impact on Starfleet's relations with the Klingons and for being the backstory for the series' protagonist, Michael Burnham.

In the 'Halo' series, notably the novel 'Halo: The Fall of Reach', this battle marks the Covenant's devastating attack on the human colony of Reach. The fall is a pivotal moment signaling the strength of the Covenant and the vulnerability of humanity.

In the game 'Halo 2', the battle takes place on a Forerunner Halo ring and involves the UNSC, Covenant, and Flood. It's significant for Master Chief's efforts to stop the ring's activation, ultimately leading to a civil war within the Covenant.

In 'Star Trek: Deep Space Nine', this battle depicts Starfleet's defense of a crucial communications relay against the Jem'Hadar. It highlights the costly nature of war and the personal toll on Starfleet personnel.

In 'Warhammer 40,000' lore, this conflict involves the forces of Chaos invading Earth, the seat of the Imperium. It's significant for being a dire threat to the heart of mankind's empire and concludes pivotal plotlines in the ongoing saga.

Though more of a thriller than a science fiction story, 'The Taking of Pelham One Two Three' involves a battle of wits between New York City transit authorities and hijackers of a subway train. Its significance lies in the suspense and the clash between order and chaos.

In 'The Lord of the Rings', Helm's Deep is the site of a major battle where the people of Rohan, aided by some heroes, defend against the armies of Saruman. Though not a conventional science fiction battle, it's a significant fantasy battle due to its emphasis on the struggle against overwhelming odds.