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Year: 1969. Highlights: First manned moon landing, Neil Armstrong and Buzz Aldrin walked on the moon. Significance: Demonstrated the USA's capability to conduct manned lunar missions and marked a significant milestone in the Space Race.

Year: 1957. Highlights: World's first artificial satellite, initiated the Space Age. Significance: Marked the beginning of the space exploration era and triggered the Space Race between the USA and USSR.

Year: 1977. Highlights: First spacecraft to reach interstellar space, famous for the 'Pale Blue Dot' image. Significance: Provided unprecedented data on the outer planets and their moons, and still sends back data from beyond our solar system.

Year: 1990. Highlights: It provided a deep view into space and time, resulted in many astronomical discoveries. Significance: Revolutionized astronomy, allowing for detailed observations of planets, stars, galaxies, and other celestial phenomena without Earth's atmospheric interference.

Year: 2012. Highlights: Largest rover sent to Mars, equipped with a full mobile laboratory. Significance: Advanced the understanding of Mars' habitability, found evidence of ancient water, and continues to analyze Martian geology and climate.

Year: 1981. Highlights: Inaugural launch of the Space Shuttle program. Significance: Marked the beginning of reusable spacecraft era and enabled numerous scientific and technological achievements in space.

Year: 2004. Highlights: First spacecraft to orbit a comet (67P/Churyumov-Gerasimenko) and deploy a lander. Significance: Gathered critical data on the comet's surface and composition, helping scientists understand the early Solar System.

Year: 2009. Highlights: Discovered thousands of exoplanets, many of which could be potentially habitable. Significance: Expanded our understanding of planets beyond the Solar System and their distribution in the galaxy.

Year: 2006. Highlights: First reconnaissance of Pluto and its moons, continued on to study the Kuiper Belt. Significance: Provided the first close-up images of Pluto, changing our understanding of the outer Solar System.

Year: 1972. Highlights: First spacecraft to travel through the asteroid belt and make direct observations of Jupiter. Significance: It paved the way for future outer planetary exploration and became the first spacecraft to achieve escape velocity from the Solar System.

Year: 2008. Highlights: India's first lunar probe, discovered water molecules on the moon’s surface. Significance: Strengthened knowledge about the lunar composition and demonstrated India’s growing capabilities in space exploration.

Year: 2004. Highlights: Investigated the geology of Mars and found evidence of past water activity. Significance: Considerably extended their planned 90-day mission lifetimes, providing invaluable data about Mars' surface and history.

Year: 2011. Highlights: Studying Jupiter's composition, gravity field, magnetic field, and polar magnetosphere. Significance: Aims to understand Jupiter's formation and evolution, which offers insights into the early Solar System.

Year: 1996. Highlights: Delivered the Sojourner rover, the first free-moving vehicle on Mars. Significance: Demonstrated a low-cost method for delivering a set of science instruments and a free-moving rover to the Red Planet.

Year: 1997. Highlights: Detailed study of Saturn and its moons, including landing the Huygens probe on Titan. Significance: Changed the understanding of Saturn's system, discovered new moons, and offered insights into Titan's surface and atmosphere.

Year: 1989. Highlights: First spacecraft to orbit Jupiter, discovered the first asteroid moon, and observed the fragmented Comet Shoemaker-Levy 9's collision with Jupiter. Significance: Increased knowledge of the Jovian system, its moons, and their geological diversity.

Year: 1998. Highlights: Intended to study Mars' climate, atmosphere, and surface changes. Significance: Although it failed due to a navigation error, the loss led to major procedural overhauls and improvements in spacecraft system engineering.

Year: 2004. Highlights: First spacecraft to orbit Mercury, provided detailed maps of Mercury's surface and composition. Significance: Enhanced understanding of the innermost planet, including its geology, magnetic field, and ice presence in shadowed craters.

Year: 1989. Highlights: Mapped 98% of Venus' surface with radar, providing high-resolution images and topographical data of the planet. Significance: Allowed for detailed study of Venus' geology, volcanoes, and landscape, vastly improving knowledge of Earth's sister planet.

Year: 2009. Highlights: Discovered water in the permanently shadowed lunar craters. Significance: Its findings of water ice have implications for understanding lunar resources and potential for supporting future lunar bases.

Year: 2018. Highlights: Deployed a seismometer and a heat-flow probe on Mars. Significance: Aims to understand the Martian interior and provide insights into the processes that shaped the rocky planets of the inner Solar System.

Year: Planning for 2022 (Knowledge cutoff 2023). Highlights: Test flight for the Artemis program, designed to return humans to the Moon. Significance: Sets the stage for future crewed lunar missions and NASA's long-term lunar exploration plans.

Year: 2014. Highlights: Sample-return mission from the asteroid Ryugu. Significance: Achieved detailed observations of an asteroid and will improve understanding of the early Solar System upon the return of the Ryugu samples to Earth.