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1969, NASA, First manned lunar landing

1981, NASA, First Space Shuttle flight

1961, Soviet space program, First human in space

1971, Soviet space program, Only humans to die in space (as of knowledge cutoff date)

2020, SpaceX/NASA, First crewed flight for a commercial spacecraft

1962, NASA, First American orbital flight

1973, NASA, First United States space station

1990, NASA, Deployment of the Hubble Space Telescope

1965, NASA, First American spacewalk

Planned (as of knowledge cutoff date), NASA, Uncrewed test flight intended to precede first woman and next man on Moon

1970, NASA, Successful failure with crippled spacecraft

2003, Chinese space agency (CNSA), First Chinese manned spaceflight

1986-2001, Soviet space program/Russian space agency (Roscosmos), Highly successful modular space station

1998-present (as of knowledge cutoff date), International collaboration, Largest human-made structure in space

1965, Soviet space program, First human spacewalk

1968, NASA, First crewed spacecraft to orbit the Moon and return

2011, NASA, Final Space Shuttle mission

2004, Scaled Composites, First privately funded manned spaceflight

1993, NASA, First Hubble Space Telescope servicing mission