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Chirality and Stereochemistry

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Racemic Mixture

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An equimolar mixture of two enantiomers, which is optically inactive due to the cancelling effect of the two enantiomers' rotations.

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Relative Configuration

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The spatial arrangement of groups around a chiral center relative to another chiral center, not necessarily specifying the exact 3D position.

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Pseudochirality

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A form of chirality that arises when a double bond or cyclic structure has different substituents, leading to geometric isomerism, that can be similar to chirality at tetrahedral centers.

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Absolute Configuration

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The precise 3D spatial arrangement of the atoms around a chirality center, described by R and S nomenclature.

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R/S (Cahn-Ingold-Prelog) Nomenclature

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A set of rules used to define the absolute configuration of a chiral center, assigning R (rectus, right) or S (sinister, left) based on the priorities of substituents.

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Meso Compound

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A compound with multiple stereocenters that possesses an internal plane of symmetry, making it achiral despite having chiral centers.

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Achiral

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Molecules that are superimposable on their mirror images, lacking chirality.

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Chiral

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Objects, including molecules, which are not superimposable on their mirror image, often possessing a center of asymmetry.

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Stereoisomers

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Isomers that have the same molecular formula and sequence of bonded atoms, but differ in the three-dimensional orientations of their atoms in space.

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Cis-Trans Isomers

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A type of diastereomerism where molecules have the same covalent bonds but differ in spatial orientation across a double bond or a ring structure.

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Chirality Center

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A carbon atom bearing four distinct substituents, serving as the source of chirality in a molecule.

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Atropisomers

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Stereoisomers resulting from restricted rotation around a bond, typically due to steric hindrance, and which can have different physical and chemical properties.

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Conformational Isomers

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Stereoisomers that can be interconverted exclusively by rotation about formally single bonds.

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Epimers

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Diastereomers that differ in configuration at only one chiral center out of several.

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Anomers

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Epimers that result from the ring formation in carbohydrates, differing at the anomeric carbon.

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Fischer Projection

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A two-dimensional representation of a molecule that depicts stereochemistry, using horizontal lines for bonds coming out of the plane and vertical lines for bonds going into the plane.

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Enantiomers

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Stereoisomers that are non-superimposable mirror images of each other.

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Resolution

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The process of separating racemic mixtures into individual enantiomers.

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Diastereomers

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Stereoisomers that are not mirror images of each other and are not superimposable.

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Optical Activity

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The ability of a chiral molecule to rotate the plane of polarized light.

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