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Mercury-Atlas 6, First American to orbit Earth, February 20, 1962

Mercury-Redstone 3, Apollo 14, First American in space, Fifth person to walk on the Moon

STS-103, STS-118, Soyuz TMA-01M, One Year Mission on ISS

Gemini 3, Gemini 10, Apollo 10, Apollo 16, STS-1, STS-9, Walked on the Moon, First Space Shuttle mission

Apollo 11, Second person to walk on the Moon, July 20, 1969

STS-8, STS-61-A, STS-39, STS-53, First African American in space

Vostok 1, First human in space, April 12, 1961

STS-63, STS-84, STS-93, STS-114, First female Shuttle Pilot, First female Shuttle Commander

STS-127, Expedition 35/36, Expedition 63, SEAL in U.S. Navy

STS-41-G, STS-31, STS-45, First American woman to walk in space

Expedition 50/51, Expedition 65/66, First French commander of the ISS

Apollo 11, First person to walk on the Moon, July 20, 1969

STS-74, STS-100, Expedition 35, First Canadian to command the ISS

STS-47, First African American woman in space, September 12, 1992

Expedition 5, Expedition 16, Expedition 50/51, Most time in space by an American astronaut

STS-56, STS-66, STS-96, STS-110, First Hispanic woman in space

STS-7, STS-41-G, First American woman in space, 1983

Gemini 10, Apollo 11, Command Module Pilot for the first Moon landing mission

Vostok 6, First woman in space, June 16, 1963