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Crew: John W. Young, Robert L. Crippen; Spacecraft: Space Shuttle Columbia; Launch Date: April 12, 1981; Significant Events: First space shuttle flight.

Crew: Pavel Belyayev, Alexei Leonov; Spacecraft: Voskhod 2; Launch Date: March 18, 1965; Significant Events: First human spacewalk by Alexei Leonov.

Crew: Charles Conrad, Paul J. Weitz, Joseph P. Kerwin; Spacecraft: Skylab; Launch Date: May 25, 1973 (crewed launch); Significant Events: First crewed mission to the Skylab space station, notable for repairs made to the station.

Crew: Thomas Stafford, Vance Brand, Donald Slayton, Alexei Leonov, Valeri Kubasov; Spacecraft: Apollo Command/Service Module, Soyuz 19; Launch Date: July 15, 1975; Significant Events: First joint U.S.-Soviet space flight, marked the end of the Space Race.

Crew: Byron K. Lichtenberg, Ulf Merbold, etc. (part of STS-9); Spacecraft: Space Shuttle Columbia; Launch Date: November 28, 1983; Significant Events: First flight of the European-built Spacelab laboratory.

Crew: Uncrewed; Spacecraft: Mars Pathfinder; Launch Date: December 4, 1996; Significant Events: Delivered the Sojourner rover, first successful rover mission on Mars.

Crew: Neil Armstrong, Buzz Aldrin, Michael Collins; Spacecraft: Command Module Columbia, Lunar Module Eagle; Launch Date: July 16, 1969; Significant Events: First manned Moon landing.

Crew: Uncrewed; Spacecraft: New Horizons; Launch Date: January 19, 2006; Significant Events: First reconnaissance of Pluto and its moons, continued on to study the Kuiper Belt.

Crew: Francis R. Scobee, Michael J. Smith, Ronald McNair, Ellison Onizuka, Judith Resnik, Gregory Jarvis, Christa McAuliffe; Spacecraft: Space Shuttle Challenger; Launch Date: January 28, 1986; Significant Events: Broke apart shortly after launch, no survivors.

Crew: Uncrewed; Spacecraft: Viking 1 Lander and Orbiter; Launch Date: August 20, 1975; Significant Events: First successful landing on Mars, returned the first close-up photos of the Martian surface.

Crew: Rick D. Husband, William C. McCool, Michael P. Anderson, Ilan Ramon, Kalpana Chawla, David M. Brown, Laurel B. Clark; Spacecraft: Space Shuttle Columbia; Launch Date: January 16, 2003; Significant Events: Disintegrated on re-entry, entire crew was lost.

Crew: James McDivitt, Edward H. White II; Spacecraft: Gemini 4; Launch Date: June 3, 1965; Significant Events: First American spacewalk (EVA) by Edward White.

Crew: Frank Borman, James A. Lovell, William A. Anders; Spacecraft: Command Module Apollo 8; Launch Date: December 21, 1968; Significant Events: First crewed spacecraft to orbit the Moon and return.

Crew: Alexander Samokutyayev, Elena Serova, Barry Wilmore; Spacecraft: Soyuz TMA-14M; Launch Date: September 25, 2014; Significant Events: Solar panel malfunction on spacecraft.

Crew: Yuri Gagarin; Spacecraft: Vostok 1; Launch Date: April 12, 1961; Significant Events: First human in space.

Crew: John Glenn; Spacecraft: Friendship 7; Launch Date: February 20, 1962; Significant Events: First American to orbit the Earth.

Crew: Georgi Dobrovolski, Viktor Patsayev, Vladislav Volkov; Spacecraft: Soyuz 11; Launch Date: June 6, 1971; Significant Events: Crew died due to a cabin depressurization during return to Earth.