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First American in space and fifth man on the Moon, missions: Mercury-Redstone 3, Apollo 14

First African American woman in space, mission: STS-47

First Hispanic woman in space, missions: STS-56, STS-66, STS-96, STS-110

Second human to walk on the Moon, missions: Gemini 12, Apollo 11

Astronaut with the longest time spent in space by an American, missions: Expedition 5, 16, 50/51

First human to walk on the Moon, missions: Gemini 8, Apollo 11

First American to orbit Earth, missions: Mercury-Atlas 6, STS-95

First African American in space, missions: STS-8, STS-61-A, STS-39, STS-53

First human to journey into outer space, mission: Vostok 1

First American woman in space, missions: STS-7, STS-41-G

First American woman to walk in space, missions: STS-41-G, STS-31, STS-45

First woman to fly to space, mission: Vostok 6

First Canadian to walk in space, missions: STS-74, STS-100, Soyuz TMA-07M

Second human to orbit the Earth, youngest-ever cosmonaut, mission: Vostok 2