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Dedicated science and research mission. Outcome: Tragic loss of crew and orbiter during re-entry.

Launched the Chandra X-ray Observatory. Outcome: Placed Chandra successfully into orbit to observe high-energy regions of the universe.

Final mission of Endeavour, delivered the Alpha Magnetic Spectrometer to the ISS. Outcome: Successful installation of AMS to study cosmic rays.

First Spacelab mission to conduct experiments in space. Outcome: Successful operation of Spacelab with numerous scientific experiments completed.

First orbital test flight of NASA's Space Shuttle program. Outcome: Successful demonstration of the shuttle's capabilities.

Return to flight mission after the Challenger disaster. Outcome: Successful deployment of a communications satellite.

Final servicing mission to the Hubble Space Telescope. Outcome: Successfully extended Hubble's operational lifespan.

First operational flight of the Challenger Space Shuttle. Outcome: Successful deployment of the first Tracking and Data Relay Satellite.

Return to flight mission after the Columbia disaster. Outcome: Successful testing of new safety and repair techniques.

First night launch and landing of the Space Shuttle. Outcome: Successful deployment of an Indian communications satellite.

First mission of the Atmospheric Laboratory for Applications and Science (ATLAS-1). Outcome: Collection of valuable data on Earth's atmosphere and solar interactions.

Aimed to deploy the second Tracking and Data Relay Satellite. Outcome: Tragic loss during launch sequence.

Delivery of the Tranquility module and the Cupola to the ISS. Outcome: Expanded the living space at the ISS and added a window module for observation.

Deployment of the Hubble Space Telescope into Earth's orbit. Outcome: Successful deployment and a major milestone for astronomy.

First Space Shuttle docking with Russian space station Mir. Outcome: Marked the beginning of a new era of international cooperation in space.

Servicing Mission to repair the Hubble Space Telescope. Outcome: Successful repairs and upgrades to Hubble.

First untethered spacewalk using the Manned Maneuvering Unit. Outcome: Successful spacewalks, but issues with satellite deployment.

Final flight of Discovery, delivering components to the ISS. Outcome: Successful delivery and marking the end of an era for Discovery.

Return of John Glenn to space. Outcome: Successful collection of data on aging during spaceflight.