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Metabolic Pathways in Exercise
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Beta-Oxidation
Function: Fatty acid catabolism to generate acetyl-CoA, NADH, and FADH2. Dominates: During prolonged, low-intensity exercise when carbohydrate stores are low.
Lactic Acid Fermentation
Function: Conversion of pyruvate to lactate when oxygen is limited to regenerate NAD+ for glycolysis. Dominates: During high-intensity exercise when oxygen supply to muscle is insufficient.
Krebs Cycle (Citric Acid Cycle)
Function: Oxidizes acetyl-CoA to carbon dioxide to generate ATP, NADH, and FADH2. Dominates: During moderate-intensity, long-duration exercise.
Glycolysis
Function: Breakdown of glucose into pyruvate to generate ATP. Dominates: During high-intensity, short-duration exercise.
Protein Catabolism
Function: Breakdown of proteins into amino acids for energy production. Dominates: Typically not a dominant pathway but may increase during prolonged exercise and calorie deficit.
Phosphocreatine (PCr) Breakdown
Function: Rapid ATP production by transferring a phosphate group from PCr to ADP. Dominates: During the first few seconds of high-intensity exercise.
Oxidative Phosphorylation
Function: Uses electrons from NADH and FADH2 to create a proton gradient that drives ATP production. Dominates: During low to moderate intensity and long-duration exercise.
Gluconeogenesis
Function: Production of glucose from non-carbohydrate sources. Dominates: During long-duration exercise and times of fasting to maintain blood glucose levels.
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