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Basic Neurobiology
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What is a synapse?
A synapse is the junction between two nerve cells, where impulses pass by diffusion of a neurotransmitter.
What is hyperpolarization?
Hyperpolarization is an increase in the membrane potential of a cell, relative to the normal resting potential.
What is a microglia?
Microglia are a type of glial cell that act as the first and main form of active immune defense in the central nervous system.
What is the absolute refractory period?
The absolute refractory period is the time during which a second action potential cannot be initiated, no matter how large a stimulus is applied, typically due to Na+ channel inactivation.
What are Schwann cells?
Schwann cells are a type of glial cell found in the peripheral nervous system that wrap around nerve fibers to form the myelin sheath, which helps increase the speed of neural transmission.
What is the relative refractory period?
The relative refractory period is the time following the absolute refractory period when a neuron can fire an action potential, but only if the stimulus strength is greater than usual.
What is the peripheral nervous system (PNS)?
The peripheral nervous system (PNS) includes all of the nerves that lie outside the central nervous system and connect it to muscles, glands, and sensory receptors.
What is an action potential?
An action potential is a rapid rise and subsequent fall in voltage or membrane potential across a cellular membrane with a characteristic pattern.
What is the resting membrane potential?
The resting membrane potential is the voltage difference between the inside and the outside of a neuronal membrane when the neuron is not actively sending a signal.
What are astrocytes?
Astrocytes are star-shaped glial cells in the brain and spinal cord that have numerous functions, including providing support for neurons and regulating the transmission of electrical impulses.
What is the autonomic nervous system (ANS)?
The autonomic nervous system (ANS) is a division of the peripheral nervous system that controls involuntary body functions like heartbeat, digestion, and breathing.
What is a dendrite?
A dendrite is a branched extension of a neuron that receives impulses from other neurons and conducts them towards the cell body.
What is the blood-brain barrier?
The blood-brain barrier is a protective shielding of the brain's blood vessels, barring many substances from entering brain tissue, thus maintaining a stable environment for the brain.
What is the soma or cell body?
The soma or cell body is the bulbous, non-process portion of a neuron, containing the cell nucleus and much of the cytoplasm, where the metabolic work of the cell is done.
What is acetylcholine (ACh)?
Acetylcholine (ACh) is a neurotransmitter in the central and peripheral nervous systems that plays a key role in muscle contraction and is involved in learning and memory.
What is a neuron?
A neuron is a specialized cell transmitting nerve impulses; a nerve cell.
What is a ligand-gated ion channel?
A ligand-gated ion channel is a group of transmembrane ion channels that open in response to the binding of a chemical messenger (ligand), such as a neurotransmitter.
What is repolarization?
Repolarization is the process by which the cell membrane potential is restored to the resting membrane potential following depolarization.
What is a G-protein coupled receptor (GPCR)?
A G-protein coupled receptor (GPCR) is a large family of cell surface receptors that activate internal cellular processes through the binding of a ligand and the activation of a G-protein.
What is long-term potentiation (LTP)?
Long-term potentiation (LTP) is a long-lasting enhancement in signal transmission between two neurons that results from stimulating them synchronously.
What are glial cells?
Glial cells are non-neuronal cells in the central and peripheral nervous system that support and protect neurons.
What is an excitatory neurotransmitter?
An excitatory neurotransmitter is a chemical messenger that increases the likelihood that the neuron will fire an action potential.
What is an axon?
An axon is a long, slender projection of a neuron that typically conducts electrical impulses away from the neuron's cell body.
What is the sodium-potassium pump?
The sodium-potassium pump is a cell membrane protein that pumps three sodium ions out and two potassium ions into the cell, helping maintain the resting membrane potential.
What is a voltage-gated ion channel?
A voltage-gated ion channel is a type of ion channel that opens or closes in response to changes in the electrical membrane potential near the channel.
What is myelination?
Myelination is the process by which a fatty layer, called myelin, accumulates around nerve cells (neurons), enabling faster and more efficient transmission of electrical signals.
What is an inhibitory neurotransmitter?
An inhibitory neurotransmitter is a chemical messenger that decreases the likelihood of the neuron firing an action potential.
What is depolarization?
Depolarization is a decrease in the difference between the electric charge on the inside and the outside of the cell membrane, often leading to the generation of an action potential.
What is the all-or-none principle?
The all-or-none principle states that once a stimulus reaches the threshold, the neuron will fire an action potential at full strength, or not at all if the threshold is not reached.
What is synaptic plasticity?
Synaptic plasticity is the ability of synapses to strengthen or weaken over time, in response to increases or decreases in their activity.
What are neurotransmitters?
Neurotransmitters are chemical messengers that transmit signals across a synapse from one neuron to another 'target' neuron.
What is a reflex arc?
A reflex arc is a neurological pathway that controls an action reflex. It involves a sensory input, a processing center, and a motor output without conscious thought.
What are oligodendrocytes?
Oligodendrocytes are glial cells in the central nervous system that produce the myelin sheath around nerve fibers to facilitate electrical insulation and increase signal transmission speed.
What is the central nervous system (CNS)?
The central nervous system (CNS) is the part of the nervous system consisting of the brain and spinal cord, primarily responsible for processing information and directing responses.
What is a neurotransmitter receptor?
A neurotransmitter receptor is a type of receptor found on the surface of a cell that is specific to a neurotransmitter, enabling it to detect the signaling molecule.
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