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Basic Neurobiology

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What is a synapse?

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A synapse is the junction between two nerve cells, where impulses pass by diffusion of a neurotransmitter.

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What is hyperpolarization?

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Hyperpolarization is an increase in the membrane potential of a cell, relative to the normal resting potential.

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What is a microglia?

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Microglia are a type of glial cell that act as the first and main form of active immune defense in the central nervous system.

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What is the absolute refractory period?

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The absolute refractory period is the time during which a second action potential cannot be initiated, no matter how large a stimulus is applied, typically due to Na+ channel inactivation.

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What are Schwann cells?

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Schwann cells are a type of glial cell found in the peripheral nervous system that wrap around nerve fibers to form the myelin sheath, which helps increase the speed of neural transmission.

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What is the relative refractory period?

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The relative refractory period is the time following the absolute refractory period when a neuron can fire an action potential, but only if the stimulus strength is greater than usual.

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What is the peripheral nervous system (PNS)?

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The peripheral nervous system (PNS) includes all of the nerves that lie outside the central nervous system and connect it to muscles, glands, and sensory receptors.

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What is an action potential?

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An action potential is a rapid rise and subsequent fall in voltage or membrane potential across a cellular membrane with a characteristic pattern.

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What is the resting membrane potential?

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The resting membrane potential is the voltage difference between the inside and the outside of a neuronal membrane when the neuron is not actively sending a signal.

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What are astrocytes?

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Astrocytes are star-shaped glial cells in the brain and spinal cord that have numerous functions, including providing support for neurons and regulating the transmission of electrical impulses.

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What is the autonomic nervous system (ANS)?

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The autonomic nervous system (ANS) is a division of the peripheral nervous system that controls involuntary body functions like heartbeat, digestion, and breathing.

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What is a dendrite?

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A dendrite is a branched extension of a neuron that receives impulses from other neurons and conducts them towards the cell body.

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What is the blood-brain barrier?

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The blood-brain barrier is a protective shielding of the brain's blood vessels, barring many substances from entering brain tissue, thus maintaining a stable environment for the brain.

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What is the soma or cell body?

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The soma or cell body is the bulbous, non-process portion of a neuron, containing the cell nucleus and much of the cytoplasm, where the metabolic work of the cell is done.

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What is acetylcholine (ACh)?

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Acetylcholine (ACh) is a neurotransmitter in the central and peripheral nervous systems that plays a key role in muscle contraction and is involved in learning and memory.

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What is a neuron?

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A neuron is a specialized cell transmitting nerve impulses; a nerve cell.

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What is a ligand-gated ion channel?

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A ligand-gated ion channel is a group of transmembrane ion channels that open in response to the binding of a chemical messenger (ligand), such as a neurotransmitter.

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What is repolarization?

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Repolarization is the process by which the cell membrane potential is restored to the resting membrane potential following depolarization.

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What is a G-protein coupled receptor (GPCR)?

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A G-protein coupled receptor (GPCR) is a large family of cell surface receptors that activate internal cellular processes through the binding of a ligand and the activation of a G-protein.

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What is long-term potentiation (LTP)?

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Long-term potentiation (LTP) is a long-lasting enhancement in signal transmission between two neurons that results from stimulating them synchronously.

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What are glial cells?

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Glial cells are non-neuronal cells in the central and peripheral nervous system that support and protect neurons.

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What is an excitatory neurotransmitter?

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An excitatory neurotransmitter is a chemical messenger that increases the likelihood that the neuron will fire an action potential.

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What is an axon?

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An axon is a long, slender projection of a neuron that typically conducts electrical impulses away from the neuron's cell body.

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What is the sodium-potassium pump?

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The sodium-potassium pump is a cell membrane protein that pumps three sodium ions out and two potassium ions into the cell, helping maintain the resting membrane potential.

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What is a voltage-gated ion channel?

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A voltage-gated ion channel is a type of ion channel that opens or closes in response to changes in the electrical membrane potential near the channel.

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What is myelination?

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Myelination is the process by which a fatty layer, called myelin, accumulates around nerve cells (neurons), enabling faster and more efficient transmission of electrical signals.

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What is an inhibitory neurotransmitter?

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An inhibitory neurotransmitter is a chemical messenger that decreases the likelihood of the neuron firing an action potential.

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What is depolarization?

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Depolarization is a decrease in the difference between the electric charge on the inside and the outside of the cell membrane, often leading to the generation of an action potential.

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What is the all-or-none principle?

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The all-or-none principle states that once a stimulus reaches the threshold, the neuron will fire an action potential at full strength, or not at all if the threshold is not reached.

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What is synaptic plasticity?

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Synaptic plasticity is the ability of synapses to strengthen or weaken over time, in response to increases or decreases in their activity.

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What are neurotransmitters?

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Neurotransmitters are chemical messengers that transmit signals across a synapse from one neuron to another 'target' neuron.

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What is a reflex arc?

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A reflex arc is a neurological pathway that controls an action reflex. It involves a sensory input, a processing center, and a motor output without conscious thought.

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What are oligodendrocytes?

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Oligodendrocytes are glial cells in the central nervous system that produce the myelin sheath around nerve fibers to facilitate electrical insulation and increase signal transmission speed.

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What is the central nervous system (CNS)?

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The central nervous system (CNS) is the part of the nervous system consisting of the brain and spinal cord, primarily responsible for processing information and directing responses.

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What is a neurotransmitter receptor?

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A neurotransmitter receptor is a type of receptor found on the surface of a cell that is specific to a neurotransmitter, enabling it to detect the signaling molecule.

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