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Longevity and Genetics

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Genetic Factor: Telomere Length

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Role in Longevity and Aging: Telomeres protect chromosome ends, but shorten with each cell division, affecting cellular aging.

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Genetic Factor: Mitochondrial DNA Mutations

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Role in Longevity and Aging: Mitochondrial dysfunction due to mutations can lead to decreased energy production and increased oxidative stress.

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Genetic Factor: Apolipoprotein E (ApoE)

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Role in Longevity and Aging: Different alleles of the ApoE gene can influence lifespan and risk for age-related diseases.

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Genetic Factor: sirtuins

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Role in Longevity and Aging: Sirtuins regulate cellular processes including DNA repair, which is critical for aging and longevity.

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Genetic Factor: FOXO genes

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Role in Longevity and Aging: FOXO genes are involved in oxidative stress resistance and are associated with longevity.

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Genetic Factor: Insulin-like Growth Factor 1 (IGF-1)

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Role in Longevity and Aging: Lower levels of IGF-1 are associated with increased lifespan and reduced age-related diseases in model organisms.

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Genetic Factor: P53 Gene

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Role in Longevity and Aging: The p53 protein is involved in DNA repair and apoptosis, and its dysfunction is associated with cancer and aging.

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Genetic Factor: Autophagy-related genes

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Role in Longevity and Aging: Autophagy is a cellular process that clears out damaged components, influencing aging and longevity.

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