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Neurotransmitter Pathways

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Serotonin System

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Primary pathways include the raphe nuclei to various brain regions. Associated behaviors include mood regulation, appetite, and sleep.

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Dopamine System

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Primary pathways encompass the mesolimbic, mesocortical, and nigrostriatal pathways. Associated behaviors are reward processing, motivation, and motor function.

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Norepinephrine (Noradrenaline) System

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Major pathways include the locus coeruleus to cortical and subcortical areas. Associated behaviors include arousal, vigilance, and the stress response.

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Acetylcholine System

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Primary pathways from the basal forebrain to the hippocampus and cortex, and from the brainstem to the thalamus. Associated behaviors include learning, memory, and muscle activation.

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Glutamate System

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The main excitatory system with widespread pathways in the brain. Associated behaviors include synaptic plasticity, learning, and memory formation.

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GABA System

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Major inhibitory system in the brain, with interneurons affecting many brain regions. Associated behaviors include reducing neuronal excitability, anxiety regulation, and motor control.

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Endocannabinoid System

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Involved in modulating other neurotransmitter systems via retrograde signaling. Associated behaviors include appetite regulation, pain sensation, and mood.

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Opioid Peptide System

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Pathways include connections to pain-regulating regions of the brain and spinal cord. Associated behaviors include pain modulation, reward, and addiction.

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Histamine System

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Originate from the hypothalamus and projects throughout the brain. Associated behaviors include wakefulness, gastric secretion, and immune responses.

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Glycine System

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Primarily found in the spinal cord and brainstem. Associated behaviors include spinal reflexes and motor behaviors, and it acts primarily as an inhibitory neurotransmitter.

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