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Major Depressive Disorder

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Depressed mood

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A consistently sad, empty, or hopeless mood that is present most of the day, nearly every day.

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Diminished interest or pleasure

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A marked decrease in interest or pleasure in all or almost all activities most of the day, nearly every day.

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Significant weight change or appetite disturbance

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Unexpected weight loss or gain, or a decrease or increase in appetite nearly every day.

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Sleep disturbance

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Insomnia or hypersomnia nearly every day.

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Psychomotor agitation or retardation

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Observable by others (not merely subjective feelings of restlessness or being slowed down).

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Fatigue or loss of energy

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Feeling tired nearly every day, even after getting rest or minimal mental or physical activity.

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Feelings of worthlessness or excessive guilt

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Excessive and inappropriate guilt or feelings of worthlessness, not merely about being sick or the negative consequences of one's actions.

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Diminished ability to think or concentrate

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Indecisiveness or reduced ability to think or concentrate, apparent nearly every day, either by subjective report or as observed by others.

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Recurrent thoughts of death

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Frequent thoughts of death (not just fear of dying), recurrent suicidal ideation without a specific plan, or a suicide attempt or a specific plan for committing suicide.

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