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Hematopoiesis Process

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Hematopoietic Stem Cell (HSC)

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The multipotent stem cell that gives rise to all blood cells; resides in bone marrow.

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Common Myeloid Progenitor (CMP)

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A cell type derived from HSCs that will give rise to myeloid lineage: erythrocytes, megakaryocytes, monocytes, and granulocytes.

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Common Lymphoid Progenitor (CLP)

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A derivative of HSCs that will give rise to lymphoid lineage: B cells, T cells, and natural killer cells.

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Megakaryocyte

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A large bone marrow cell responsible for the production of thrombocytes (platelets), involved in clotting.

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Erythroblast

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An immature red blood cell (erythrocyte) that is found in bone marrow and will eventually lose its nucleus to become a mature erythrocyte.

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Erythrocyte

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A mature red blood cell responsible for oxygen transport, derived from erythroblasts.

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Myeloblast

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An immature precursor of granulocytes, found in bone marrow.

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Monocyte

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A type of white blood cell that will leave the bone marrow to become a macrophage or dendritic cell in peripheral tissues.

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B Lymphocyte (B cell)

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A type of lymphocyte responsible for producing antibodies; derived from the common lymphoid progenitor.

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T Lymphocyte (T cell)

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A type of lymphocyte involved in cell-mediated immunity; also derived from the common lymphoid progenitor.

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Natural Killer (NK) Cell

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A lymphocyte involved in the innate immune response against tumor and virally infected cells; comes from common lymphoid progenitor.

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Granulocyte

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A type of white blood cell filled with microscopic granules; includes neutrophils, eosinophils, and basophils.

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Neutrophil

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The most common type of granulocyte, crucial for fighting bacterial infections.

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Eosinophil

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A granulocyte involved in combating parasitic infections and in allergic reactions.

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Basophil

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The least common type of granulocyte; participates in allergic responses and releases histamine.

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Megakaryoblast

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The precursor cell to a megakaryocyte, involved in the production of blood thrombocytes.

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Proerythroblast

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An early stage in erythrocyte development; will mature into erythroblasts.

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Myelocyte

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A stage in the development of granulocytes and monocytes from myeloblasts.

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Megakaryocyte-erythroid Progenitor (MEP)

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A progenitor cell derived from CMP that will give rise to megakaryocytes and erythrocytes.

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Progranulocyte

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An intermediate cell stage that precedes the formation of specific types of granulocytes.

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Pluripotent Hematopoietic Stem Cell (PHSC)

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The precursor to HSC, capable of giving rise to multiple cell types, including those outside of hematopoiesis.

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Band Cell

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An immature neutrophil with a non-segmented nucleus that will mature into a segmented neutrophil.

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Plasmablast

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A precursor to plasma cell, which is an activated B cell that secretes antibodies.

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Plasma Cell

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A mature B cell that produces and secretes large quantities of antibodies; derived from plasmablasts.

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Dendritic Cell

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A type of antigen-presenting cell that processes and presents antigens to T cells; derived from monocytes.

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