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Wound Healing Stages in Dermatology

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Hemostasis

Vasoconstriction to reduce blood loss, platelet aggregation to form a clot, and cytokine release for healing initiation.

Inflammatory Phase

Characterized by redness and swelling, neutrophil invasion to prevent infection, and macrophages to clean debris.

Maturation Phase

Collagen fibers reorganize, tissue remodels and strengthens, and eventually results in scar tissue formation with decreased vascularity.

Proliferative Phase

Fibroblast proliferation, collagen deposition, granulation tissue formation, and epithelialization occur to rebuild the dermis and epidermis.

Epithelialization

Occurs throughout the healing process especially during the proliferative phase; keratinocytes migrate across the wound bed to restore the epidermis.

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