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Energy requirements of chemical processes should be minimized for their environmental and economical impact.

Unnecessary derivatization (use of blocking groups, protection/deprotection, temporary modification of physical/chemical processes) should be minimized or avoided if possible, because such processes generate waste.

It is better to prevent waste than to treat or clean up waste after it is formed.

A raw material or feedstock should be renewable rather than depleting whenever technically and economically practicable.

Chemical products should be designed to preserve efficacy of function while reducing toxicity.

The use of auxiliary substances (e.g., solvents, separation agents) should be made unnecessary whenever possible and, when used, should be innocuous.

Synthetic methods should be designed to maximize the incorporation of all materials used in the process into the final product.

Whenever practicable, synthetic methods should be designed to use and generate substances that possess little or no toxicity to human health and the environment.

Catalytic reagents (as selective as possible) are superior to stoichiometric reagents.

Analytical methodologies need to be further developed to allow for real-time, in-process monitoring and control prior to the formation of hazardous substances.

Chemical products should be designed so that at the end of their function they do not persist in the environment and break down into innocuous degradation products.