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Chromosomes and Karyotypes

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Meiosis

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A type of cell division that reduces the chromosome number by half, resulting in four haploid daughter cells, used in producing gametes for sexual reproduction.

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Telomere

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The protective cap structure at the end of a chromosome that shortens with each cell division and is involved in aging and cell death.

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Autosome

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Any chromosome that is not a sex chromosome; humans have 22 pairs of autosomes.

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Trisomy

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The condition of having an extra chromosome in most or all of the cells of an organism, leading to developmental differences or disorders such as Down syndrome (Trisomy 21).

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Phenotype

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The observable physical or biochemical characteristics of an organism as determined by both genetic makeup and environmental influences.

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Sister Chromatids

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Identical copies of a chromosome, connected by a centromere, that are produced during DNA replication.

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Karyotype

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The number and visual appearance of the chromosomes in the cell nuclei of an organism or species.

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Mitosis

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A process of cell division in which a single cell divides to produce two genetically identical daughter cells.

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Homologous Chromosomes

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Chromosome pairs, one from each parent, that are similar in length, gene position, and centromere location.

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Sex Chromosome

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Chromosomes that determine the sex of an individual; humans have one pair, with women having two X chromosomes and men one X and one Y.

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Centromere

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The region of a chromosome where the two sister chromatids attach and which is involved in cell division.

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Chromosome

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A structure made of DNA and protein in the nucleus of eukaryotic cells, consisting of a single molecule of DNA that contains the organism's genes.

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Genotype

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The genetic constitution of an individual organism, often in reference to specific traits or alleles.

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Haploid

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A cell that contains a single set of chromosomes, denoted as n, typically found in gametes (sperm and eggs).

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Non-disjunction

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The failure of chromosome pairs to separate properly during cell division which can lead to disorders such as Down syndrome.

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Diploid

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A cell that contains two sets of chromosomes, one from each parent, denoted as 2n.

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Polyploidy

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The condition of having more than two complete sets of chromosomes in a cell or an organism, common in plants and some animal species.

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Ploidy

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The number of sets of chromosomes in a cell or in the cells of an organism, represented as haploid, diploid, triploid, etc.

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Nucleosome

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The basic structural unit of DNA packaging in eukaryotes, consisting of a segment of DNA wound in sequence around eight histone protein cores.

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Euchromatin

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The less condensed form of eukaryotic chromatin that is functionally active and accessible for transcription.

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Chiasma

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The site where crossover and exchange of genetic material occurs between homologous chromosomes during meiosis.

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Cytogenetics

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The field of genetics that pertains to the structure and function of chromosomes, including karyotyping and chromosome analysis.

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Aneuploidy

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A condition in which one or a few chromosomes are either missing or present in excess, leading to a deviation from an organism's normal chromosome number.

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Monosomy

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The condition of having a single copy of a chromosome instead of the usual pair, often leading to severe developmental disorders or pregnancy loss.

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Heterochromatin

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The highly condensed form of chromatin that is transcriptionally inactive, often found around the centromere and telomeres.

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