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Chromosomes and Karyotypes
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Meiosis
A type of cell division that reduces the chromosome number by half, resulting in four haploid daughter cells, used in producing gametes for sexual reproduction.
Telomere
The protective cap structure at the end of a chromosome that shortens with each cell division and is involved in aging and cell death.
Autosome
Any chromosome that is not a sex chromosome; humans have 22 pairs of autosomes.
Trisomy
The condition of having an extra chromosome in most or all of the cells of an organism, leading to developmental differences or disorders such as Down syndrome (Trisomy 21).
Phenotype
The observable physical or biochemical characteristics of an organism as determined by both genetic makeup and environmental influences.
Sister Chromatids
Identical copies of a chromosome, connected by a centromere, that are produced during DNA replication.
Karyotype
The number and visual appearance of the chromosomes in the cell nuclei of an organism or species.
Mitosis
A process of cell division in which a single cell divides to produce two genetically identical daughter cells.
Homologous Chromosomes
Chromosome pairs, one from each parent, that are similar in length, gene position, and centromere location.
Sex Chromosome
Chromosomes that determine the sex of an individual; humans have one pair, with women having two X chromosomes and men one X and one Y.
Centromere
The region of a chromosome where the two sister chromatids attach and which is involved in cell division.
Chromosome
A structure made of DNA and protein in the nucleus of eukaryotic cells, consisting of a single molecule of DNA that contains the organism's genes.
Genotype
The genetic constitution of an individual organism, often in reference to specific traits or alleles.
Haploid
A cell that contains a single set of chromosomes, denoted as n, typically found in gametes (sperm and eggs).
Non-disjunction
The failure of chromosome pairs to separate properly during cell division which can lead to disorders such as Down syndrome.
Diploid
A cell that contains two sets of chromosomes, one from each parent, denoted as 2n.
Polyploidy
The condition of having more than two complete sets of chromosomes in a cell or an organism, common in plants and some animal species.
Ploidy
The number of sets of chromosomes in a cell or in the cells of an organism, represented as haploid, diploid, triploid, etc.
Nucleosome
The basic structural unit of DNA packaging in eukaryotes, consisting of a segment of DNA wound in sequence around eight histone protein cores.
Euchromatin
The less condensed form of eukaryotic chromatin that is functionally active and accessible for transcription.
Chiasma
The site where crossover and exchange of genetic material occurs between homologous chromosomes during meiosis.
Cytogenetics
The field of genetics that pertains to the structure and function of chromosomes, including karyotyping and chromosome analysis.
Aneuploidy
A condition in which one or a few chromosomes are either missing or present in excess, leading to a deviation from an organism's normal chromosome number.
Monosomy
The condition of having a single copy of a chromosome instead of the usual pair, often leading to severe developmental disorders or pregnancy loss.
Heterochromatin
The highly condensed form of chromatin that is transcriptionally inactive, often found around the centromere and telomeres.
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