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Non-Mendelian Inheritance

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Multiple Alleles

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A form of inheritance where more than two alleles determine the phenotype. Example: Human blood types (A, B, O), where there are three alleles (IA, IB, i) for blood type.

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Mitochondrial Inheritance

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Inheritance of genetic traits carried on mitochondrial DNA, which is exclusively passed down from mother to offspring. Example: Mitochondrial diseases such as Leber's hereditary optic neuropathy (LHON).

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Environmental Influence on Gene Expression

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The concept that the environment can directly influence the expression of genes and thus the phenotype. Example: The Himalayan rabbit, which develops darker fur on the cooler parts of its body.

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Epistasis

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A phenomenon where the effects of one gene are modified by one or several other genes, which are sometimes called modifier genes. Example: Coat color in Labrador retrievers, where one gene determines pigment while another controls pigment deposition.

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Mosaicism

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The presence of two or more populations of cells with different genotypes in an individual who has developed from a single fertilized egg. Example: Calico cats, which have patches of different coloration due to X-inactivation.

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Incomplete Dominance

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A type of inheritance in which the phenotype of a heterozygote is intermediate between the phenotypes of the two homozygotes. Example: The snapdragon flower, where red (RR) and white (WW) parents produce pink (RW) offspring.

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Genomic Imprinting

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A form of inheritance where the expression of a gene depends on whether it was inherited from the mother or the father. Example: Prader-Willi and Angelman syndromes, which involve the same chromosomal region but differ based on parental origin.

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Maternal Effect

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When the phenotype of the offspring is determined by the genotype of the mother. Example: Shell coiling direction in the snail Limnaea peregra.

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Polygenic Inheritance

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A type of inheritance where a trait is governed by two or more genes, resulting in a wide range of possible phenotypes. Example: Human skin color, height.

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Pleiotropy

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When one gene influences multiple, seemingly unrelated phenotypic traits. Example: Marfan syndrome in humans, where a single gene can affect the skeletal system, cardiovascular system, and eyes.

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Sex-Linked Traits

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Traits that are associated with genes located on the sex chromosomes. Example: Color blindness and hemophilia in humans, which are often X-linked disorders.

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Codominance

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A type of inheritance where two alleles are both expressed in the heterozygous condition, resulting in a phenotype that displays both traits simultaneously. Example: Blood type AB in humans, where alleles A and B are both expressed.

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Anticipation

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A genetic phenomenon where the severity or age of onset of a genetic disorder increases in successive generations. Example: Huntington’s disease, where onset often gets earlier as it is passed down.

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Cytoplasmic Inheritance

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Inheritance of traits controlled by genes located in the cytoplasm, often transmitted through the maternal cytoplasm in the egg. Example: Leaf variegation in plants like the four o'clock flower.

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Uniparental Disomy

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A condition in which both copies of a chromosome are inherited from one parent. Example: Prader-Willi syndrome can also be caused by uniparental disomy of chromosome 15, if both copies are from the mother.

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