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Transplant Surgery Basics
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Autograft
A transplant of tissue from one part of the body to another part of the same individual's body. It applies to skin grafts and bone grafts commonly.
Allograft
A transplant of cells, tissues, or organs to a recipient from a genetically nonidentical donor of the same species. Types include kidney, liver, and heart transplants.
Xenograft
A transplant of cells, tissues, or organs from a donor of one species to a recipient of another species. This concept is explored in heart valves from pigs.
Isograft
A transplant between two genetically identical individuals, like identical twins. This is rare and applies to very few types of transplants like kidney or bone marrow.
Organ Rejection
The recipient's immune system attacks the transplanted organ or tissue. It is a concern in allografts and xenografts.
Immunosuppression
Use of medications to reduce the immune response and prevent organ rejection. Applies to allografts and sometimes xenografts.
HLA Matching
Human Leukocyte Antigen matching involves comparing the donor's and recipient's HLA markers to predict the risk of rejection, primarily in allografts.
Deceased Donor
An organ donation from a person who has been declared brain dead but whose organs are still functioning. Impacts heart, kidney, lung, and liver transplants.
Living Donor
A live individual donates a transplantable organ or part of one, such as a kidney or a liver lobe. Enables planned surgeries and reduces waiting times.
Graft-versus-Host Disease (GvHD)
A complication where transplanted donor cells attack the recipient's body; most often associated with bone marrow transplants.
Immunological Tolerance
A state where the recipient's immune system does not attack the donor's organ or tissue. Aimed for in all transplants, especially in allografts and xenografts.
Engraftment
The successful take and function of the graft or transplant in the host body. It is critical in bone marrow and stem cell transplants.
Crossmatch Test
A blood test to check if the recipient has antibodies against the donor's antigens. Critical in kidney and sometimes heart transplants.
Warm Ischemia Time
The duration when an organ remains at body temperature after blood supply has been cut off, but before it is cooled or transplanted. Critical in kidney and liver transplants.
Cold Ischemia Time
The time that an organ is cooled with a preservative solution after being removed from the donor and before it is transplanted. Pivotal in heart and lung transplants.
Donor Specific Antibody (DSA)
Antibodies formed by the recipient against the HLA molecules of the graft donor, which can lead to rejection. Commonly associated with kidney and heart allografts.
ABO Incompatible Transplant
A transplant where the donor and recipient have different blood types. New techniques allow for this in some kidney transplants.
Immune Desensitization
A process that reduces the recipient's antibody levels before transplantation to prevent rejection. This is used in ABO incompatible and positive crossmatch kidney transplants.
Transplant Ethics
The moral principles that affect transplantation policies and practices, such as allocation of organs, informed consent, and donor compensation. Concerns all types of transplants.
Cadaveric Donor
Refers to a deceased donor from whom organs or tissues are harvested for transplantation. Affects organ supply for most transplant types.
Transplant Tourism
Traveling to another country for the purpose of receiving an organ transplant, often because of the shortage of organs in one's own country. Raises ethical and health concerns.
Transplant Pharmacist
A pharmacist specializing in managing medications before and after transplant surgery, ensuring proper dosing and monitoring for side effects. Crucial in all allograft transplants.
Conditioning Regimen
A treatment given to prepare the recipient's body for a transplant, such as chemotherapy or radiation before a bone marrow transplant. Essential to achieving engraftment in stem cell transplants.
Panel Reactive Antibody (PRA)
The level of sensitization of a transplant candidate to potential donors, measured as a percentage. High PRA increases the difficulty of finding a compatible donor, notably in kidney transplants.
Split Liver Transplantation
A technique where a liver from a deceased donor is divided into two parts for transplantation into two recipients. Optimizes the use of available organs.
Bridge to Transplant
A temporary treatment given to patients awaiting organ transplantation, such as ventricular assist devices for heart transplant candidates. Aims to stabilize the patient until a donor organ is available.
Transplant Coordinator
A healthcare professional who manages the care of transplant patients and coordinates the transplant process. Integral team member for all types of transplants.
Transplant Rejection Prophylaxis
The prevention strategies employed to protect against transplant rejection, including immunosuppressive medications. Essential in preventing rejection in allografts.
Kidney Paired Donation (KPD)
A transplant option for candidates with a living donor who is medically suitable but not compatible, where two or more donor-recipient pairs are matched for a swap. Increases chances of compatible living donor transplants.
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