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Anticoagulant and Thrombolytic Drugs

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Prasugrel

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Mechanism of Action: ADP receptor inhibitor; Use: Reduction of thrombotic cardiovascular events in patients with acute coronary syndrome

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Clopidogrel

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Mechanism of Action: ADP receptor inhibitor; Use: Reduction of atherosclerotic events

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Warfarin

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Mechanism of Action: Inhibits vitamin K epoxide reductase; Use: Long-term anticoagulation

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Aspirin

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Mechanism of Action: Inhibits cyclooxygenase (COX); Use: Prevention of heart attacks and strokes

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Vorapaxar

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Mechanism of Action: Protease-activated receptor-1 (PAR-1) antagonist; Use: Reduction of thrombotic cardiovascular events

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Urokinase

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Mechanism of Action: Directly converts plasminogen to plasmin; Use: Pulmonary embolism and clearing occluded catheters

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Rivaroxaban

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Mechanism of Action: Factor Xa inhibitor; Use: Treatment and prevention of deep vein thrombosis and pulmonary embolism

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Fondaparinux

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Mechanism of Action: Synthetic pentasaccharide that selectively inhibits factor Xa; Use: Treatment of deep vein thrombosis and pulmonary embolism

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Streptokinase

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Mechanism of Action: Forms a complex with plasminogen; Use: Treatment of acute myocardial infarction

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Dabigatran

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Mechanism of Action: Direct thrombin inhibitor; Use: Stroke prevention in atrial fibrillation

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Heparin

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Mechanism of Action: Potentiates the action of antithrombin III; Use: Treatment of venous thromboembolism

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Tirofiban

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Mechanism of Action: Glycoprotein IIb/IIIa receptor antagonist; Use: Acute coronary syndrome

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Dalteparin

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Mechanism of Action: Low-molecular-weight heparin; Use: Prevention of deep vein thrombosis, treatment of acute coronary syndrome

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Ticagrelor

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Mechanism of Action: ADP receptor inhibitor; Use: Reduction of thrombotic cardiovascular events in patients with acute coronary syndrome

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Enoxaparin

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Mechanism of Action: Low-molecular-weight heparin; Use: Prevention of deep vein thrombosis and treatment of acute coronary syndrome

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Edoxaban

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Mechanism of Action: Factor Xa inhibitor; Use: Treatment of deep vein thrombosis and pulmonary embolism after initial therapy

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Argatroban

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Mechanism of Action: Direct thrombin inhibitor; Use: Prophylaxis and treatment of thrombosis in heparin-induced thrombocytopenia

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Apixaban

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Mechanism of Action: Factor Xa inhibitor; Use: Reduction of stroke risk in patients with non-valvular atrial fibrillation

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Bivalirudin

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Mechanism of Action: Direct thrombin inhibitor; Use: Percutaneous coronary intervention

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Alteplase

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Mechanism of Action: Converts plasminogen to plasmin; Use: Acute myocardial infarction, stroke, and pulmonary embolism

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