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Anticoagulant and Thrombolytic Drugs
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Heparin
Mechanism of Action: Potentiates the action of antithrombin III; Use: Treatment of venous thromboembolism
Warfarin
Mechanism of Action: Inhibits vitamin K epoxide reductase; Use: Long-term anticoagulation
Dabigatran
Mechanism of Action: Direct thrombin inhibitor; Use: Stroke prevention in atrial fibrillation
Rivaroxaban
Mechanism of Action: Factor Xa inhibitor; Use: Treatment and prevention of deep vein thrombosis and pulmonary embolism
Apixaban
Mechanism of Action: Factor Xa inhibitor; Use: Reduction of stroke risk in patients with non-valvular atrial fibrillation
Edoxaban
Mechanism of Action: Factor Xa inhibitor; Use: Treatment of deep vein thrombosis and pulmonary embolism after initial therapy
Fondaparinux
Mechanism of Action: Synthetic pentasaccharide that selectively inhibits factor Xa; Use: Treatment of deep vein thrombosis and pulmonary embolism
Clopidogrel
Mechanism of Action: ADP receptor inhibitor; Use: Reduction of atherosclerotic events
Aspirin
Mechanism of Action: Inhibits cyclooxygenase (COX); Use: Prevention of heart attacks and strokes
Tirofiban
Mechanism of Action: Glycoprotein IIb/IIIa receptor antagonist; Use: Acute coronary syndrome
Alteplase
Mechanism of Action: Converts plasminogen to plasmin; Use: Acute myocardial infarction, stroke, and pulmonary embolism
Streptokinase
Mechanism of Action: Forms a complex with plasminogen; Use: Treatment of acute myocardial infarction
Urokinase
Mechanism of Action: Directly converts plasminogen to plasmin; Use: Pulmonary embolism and clearing occluded catheters
Argatroban
Mechanism of Action: Direct thrombin inhibitor; Use: Prophylaxis and treatment of thrombosis in heparin-induced thrombocytopenia
Bivalirudin
Mechanism of Action: Direct thrombin inhibitor; Use: Percutaneous coronary intervention
Enoxaparin
Mechanism of Action: Low-molecular-weight heparin; Use: Prevention of deep vein thrombosis and treatment of acute coronary syndrome
Dalteparin
Mechanism of Action: Low-molecular-weight heparin; Use: Prevention of deep vein thrombosis, treatment of acute coronary syndrome
Prasugrel
Mechanism of Action: ADP receptor inhibitor; Use: Reduction of thrombotic cardiovascular events in patients with acute coronary syndrome
Ticagrelor
Mechanism of Action: ADP receptor inhibitor; Use: Reduction of thrombotic cardiovascular events in patients with acute coronary syndrome
Vorapaxar
Mechanism of Action: Protease-activated receptor-1 (PAR-1) antagonist; Use: Reduction of thrombotic cardiovascular events
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