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Chemotherapy Agents
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Carboplatin
Alkylating-like, forms DNA crosslinks
Thalidomide
Immunomodulatory drug, inhibits angiogenesis
Methotrexate
Antimetabolite, inhibits dihydrofolate reductase
Tamoxifen
Selective estrogen receptor modulator (SERM), antagonist in breast
Sorafenib
Tyrosine kinase inhibitor, multiple targets including VEGFR and PDGFR
Cyclophosphamide
Alkylating agent, forms DNA crosslinks
Letrozole
Aromatase inhibitor, decreases estrogen production
Trastuzumab
Monoclonal antibody, targets HER2/neu receptor
Rituximab
Monoclonal antibody, targets CD20 on B cells
Bevacizumab
Monoclonal antibody, inhibits vascular endothelial growth factor (VEGF)
Irinotecan
Topoisomerase I inhibitor, prevents DNA relegation
Topotecan
Topoisomerase I inhibitor, prevents DNA relegation
Paclitaxel
Mitotic inhibitor, stabilizes microtubules
Cisplatin
Alkylating agent, forms DNA crosslinks
Doxorubicin
Anthracycline, intercalates DNA and inhibits topoisomerase II
Nivolumab
Monoclonal antibody, PD-1 inhibitor
Temozolomide
Alkylating agent, methylates DNA
Bleomycin
Antitumor antibiotic, causes DNA strand breaks
Imatinib
Tyrosine kinase inhibitor, inhibits BCR-ABL oncoprotein
Lenalidomide
Immunomodulatory drug, inhibits angiogenesis and modulates immune response
Vincristine
Mitotic inhibitor, inhibits microtubule formation
5-Fluorouracil (5-FU)
Antimetabolite, inhibits thymidylate synthase
Etoposide
Topoisomerase II inhibitor, leads to DNA strand breaks
Bortezomib
Proteasome inhibitor, prevents protein degradation
Pembrolizumab
Monoclonal antibody, PD-1/PD-L1 inhibitor
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