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Chemotherapy Agents
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Temozolomide
Alkylating agent, methylates DNA
Rituximab
Monoclonal antibody, targets CD20 on B cells
Irinotecan
Topoisomerase I inhibitor, prevents DNA relegation
Vincristine
Mitotic inhibitor, inhibits microtubule formation
Cisplatin
Alkylating agent, forms DNA crosslinks
Bevacizumab
Monoclonal antibody, inhibits vascular endothelial growth factor (VEGF)
5-Fluorouracil (5-FU)
Antimetabolite, inhibits thymidylate synthase
Sorafenib
Tyrosine kinase inhibitor, multiple targets including VEGFR and PDGFR
Tamoxifen
Selective estrogen receptor modulator (SERM), antagonist in breast
Etoposide
Topoisomerase II inhibitor, leads to DNA strand breaks
Nivolumab
Monoclonal antibody, PD-1 inhibitor
Imatinib
Tyrosine kinase inhibitor, inhibits BCR-ABL oncoprotein
Bortezomib
Proteasome inhibitor, prevents protein degradation
Thalidomide
Immunomodulatory drug, inhibits angiogenesis
Pembrolizumab
Monoclonal antibody, PD-1/PD-L1 inhibitor
Cyclophosphamide
Alkylating agent, forms DNA crosslinks
Bleomycin
Antitumor antibiotic, causes DNA strand breaks
Letrozole
Aromatase inhibitor, decreases estrogen production
Doxorubicin
Anthracycline, intercalates DNA and inhibits topoisomerase II
Paclitaxel
Mitotic inhibitor, stabilizes microtubules
Trastuzumab
Monoclonal antibody, targets HER2/neu receptor
Carboplatin
Alkylating-like, forms DNA crosslinks
Lenalidomide
Immunomodulatory drug, inhibits angiogenesis and modulates immune response
Methotrexate
Antimetabolite, inhibits dihydrofolate reductase
Topotecan
Topoisomerase I inhibitor, prevents DNA relegation
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