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Chemotherapy Agents
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Methotrexate
Antimetabolite, inhibits dihydrofolate reductase
5-Fluorouracil (5-FU)
Antimetabolite, inhibits thymidylate synthase
Cisplatin
Alkylating agent, forms DNA crosslinks
Doxorubicin
Anthracycline, intercalates DNA and inhibits topoisomerase II
Paclitaxel
Mitotic inhibitor, stabilizes microtubules
Tamoxifen
Selective estrogen receptor modulator (SERM), antagonist in breast
Imatinib
Tyrosine kinase inhibitor, inhibits BCR-ABL oncoprotein
Trastuzumab
Monoclonal antibody, targets HER2/neu receptor
Bevacizumab
Monoclonal antibody, inhibits vascular endothelial growth factor (VEGF)
Rituximab
Monoclonal antibody, targets CD20 on B cells
Cyclophosphamide
Alkylating agent, forms DNA crosslinks
Carboplatin
Alkylating-like, forms DNA crosslinks
Vincristine
Mitotic inhibitor, inhibits microtubule formation
Bleomycin
Antitumor antibiotic, causes DNA strand breaks
Etoposide
Topoisomerase II inhibitor, leads to DNA strand breaks
Irinotecan
Topoisomerase I inhibitor, prevents DNA relegation
Bortezomib
Proteasome inhibitor, prevents protein degradation
Thalidomide
Immunomodulatory drug, inhibits angiogenesis
Lenalidomide
Immunomodulatory drug, inhibits angiogenesis and modulates immune response
Pembrolizumab
Monoclonal antibody, PD-1/PD-L1 inhibitor
Nivolumab
Monoclonal antibody, PD-1 inhibitor
Sorafenib
Tyrosine kinase inhibitor, multiple targets including VEGFR and PDGFR
Temozolomide
Alkylating agent, methylates DNA
Topotecan
Topoisomerase I inhibitor, prevents DNA relegation
Letrozole
Aromatase inhibitor, decreases estrogen production
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