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Serotonin Syndrome: High-risk Medications

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Fluoxetine

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High

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Linezolid

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Moderate

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SSRIs + MAOIs

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Very High

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MAOIs (e.g., Phenelzine)

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Very High

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LSD

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Moderate

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Citalopram

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High

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Mirtazapine

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Low to Moderate

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Sertraline

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High

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St. John's Wort

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Moderate

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Dextromethorphan

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Moderate

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Chlorpheniramine

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Low

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Methadone

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Moderate

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MDMA (Ecstasy)

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Very High

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Tramadol

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Moderate to High

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Venlafaxine

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High

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