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Drug Classes and Mechanisms
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ACE Inhibitors
Block the conversion of angiotensin I to angiotensin II
Tricyclic Antidepressants
Block reuptake of norepinephrine and serotonin into the presynaptic neuron
Aminoglycoside Antibiotics
Bind to the 30S subunit of the bacterial ribosome, causing misreading of mRNA
MAO Inhibitors
Inhibit monoamine oxidase, an enzyme that breaks down neurotransmitters
Alkylating Agents
Attach alkyl groups to DNA, interfering with DNA replication and transcription
Beta Blockers
Competitively block beta-adrenergic receptors
Antimetabolites
Mimic natural substances, interfering with cell growth and division
Antifungal - Azoles
Inhibit the synthesis of ergosterol, a key component of the fungal cell membrane
Proton Pump Inhibitors
Irreversibly bind to and inhibit the hydrogen/potassium ATPase enzyme in parietal cells
H2 Receptor Antagonists
Competitively block histamine H2 receptors on parietal cells in the stomach
Calcium Channel Blockers
Inhibit the entry of calcium ions into cardiac and smooth muscle cells
Statins
Inhibit HMG-CoA reductase
Sulfonylureas
Increase insulin release from the beta cells in the pancreas
Nitrates
Cause vasodilation by increasing nitric oxide in vascular smooth muscle
Beta-Lactam Antibiotics
Inhibit the synthesis of bacterial cell walls
Thiazolidinediones
Activate PPAR-gamma, a type of nuclear regulatory protein
NSAIDs
Inhibit cyclooxygenase (COX) enzymes
Biguanides
Decrease glucose production by the liver and increase insulin sensitivity
SSRIs
Inhibit the reuptake of serotonin into the presynaptic cell
Benzodiazepines
Enhance the effect of the neurotransmitter gamma-aminobutyric acid (GABA)
Antivirals for Influenza
Neuraminidase inhibitors prevent the release of new influenza virus particles
Monoclonal Antibodies
Specifically target and bind to antigens, such as those found on cancer cells or involved in immune responses
Tyrosine Kinase Inhibitors
Inhibit the action of tyrosine kinases, which are enzymes involved in many cell functions including cell signaling, growth, and division
Opioids
Bind to opioid receptors in the central and peripheral nervous system
Macrolide Antibiotics
Inhibit bacterial protein synthesis by binding to the 50S subunit of the ribosome
Antivirals - HIV Protease Inhibitors
Inhibit the HIV protease enzyme, preventing viral replication
Corticosteroids
Mimic the effects of hormones produced by the adrenal glands and have multiple effects, including anti-inflammatory
Diuretics
Increase the excretion of water and electrolytes from the body
Phosphodiesterase Inhibitors
Inhibit the phosphodiesterase enzyme, leading to increased levels of cyclic AMP
Immunosuppressants
Prevent or inhibit the immune response
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