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Pediatric Nephrology

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Hydronephrosis

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Presents due to the dilation of the renal pelvis and calyces, can be due to obstruction or reflux. Management includes addressing the underlying cause and protecting renal function.

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Wilms Tumor

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Presents with an asymptomatic abdominal mass, occasionally with hematuria or hypertension. Managed primarily with surgery and chemotherapy, and prognosis is generally good with treatment.

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Reflux Nephropathy

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Characterized by recurrent urinary tract infections and vesicoureteral reflux. Managed with antibiotics, surgery for severe cases, and monitoring for renal scarring and hypertension.

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Minimal Change Disease

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Presents with sudden onset of edema and nephrotic syndrome, but with normal kidney function. Managed with corticosteroids, and most children respond well to the treatment.

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Cystinosis

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Presents with renal Fanconi syndrome, growth failure, and rickets. Management involves replacing lost electrolytes, using cysteamine therapy, and monitoring for kidney complications.

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Hemolytic Uremic Syndrome

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Presents with a triad of hemolytic anemia, thrombocytopenia, and acute kidney injury, often after a diarrheal illness caused by E.coli. Management includes supportive care, dialysis if needed, and close monitoring.

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Acute Poststreptococcal Glomerulonephritis

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Presents with hematuria, hypertension, edema following a strep infection. Managed with supportive care, antibiotics if strep infection is ongoing, and blood pressure control.

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Polycystic Kidney Disease

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Presents with hypertension, urinary tract infections, hematuria, and kidney stones. Management involves blood pressure control, treatment of urinary infections, and monitoring for renal function.

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Nephrotic Syndrome

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Characterized by proteinuria, hypoalbuminemia, hyperlipidemia, and edema. Management includes corticosteroids for most cases, and possibly immunosuppressants for steroid-resistant types.

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Chronic Kidney Disease

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Progressive loss of renal function over time; presents with symptoms of uremia, hypertension, and growth failure. Management includes protecting remaining renal function, managing complications, and preparing for renal replacement therapy if needed.

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Acute Kidney Injury

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Can be due to pre-renal, intrinsic renal, or post-renal causes. Presents with oliguria or anuria, fluid overload, and elevated serum creatinine. Management is based on the cause and may include fluid management, dialysis, and medication adjustment.

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Urolithiasis (Kidney Stones)

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Presents with pain, hematuria, and possible urinary tract infection. Management includes pain control, hydration, possible medical expulsive therapy, and in some cases, surgical intervention.

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Alport Syndrome

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Characterized by hematuria, progressive renal failure, and often sensorineural hearing loss. Management is supportive and may include ACE inhibitors, hearing aids, and ultimately renal transplantation.

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Obstructive Uropathy

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Can present with urinary tract infections, poor growth, or renal failure. Management depends on the cause, ranging from surgical intervention to observation.

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Henoch-Schönlein Purpura Nephritis

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Presents with a purpuric rash, abdominal pain, arthralgia, hematuria. Management includes supportive care, steroids for severe cases, and monitoring for renal function deterioration.

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