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Skull Foramina and Contents

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Superior Orbital Fissure

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Structures: Oculomotor nerve (CN III), trochlear nerve (CN IV), abducens nerve (CN VI), ophthalmic division of trigeminal nerve (CN V1), and superior ophthalmic vein. Clinical relevance: Lesions here may result in ophthalmoplegia.

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Foramen Rotundum

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Structures: Maxillary division of trigeminal nerve (CN V2). Clinical relevance: Can be a site for anesthetic injections to block pain in maxillary area.

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Jugular Foramen

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Structures: Glossopharyngeal nerve (CN IX), vagus nerve (CN X), accessory nerve (CN XI), and internal jugular vein. Clinical relevance: Jugular foramen syndrome affects multiple cranial nerves leading to a variety of symptoms like dysphonia, dysphagia, and loss of gag reflex.

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Stylomastoid Foramen

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Structures: Facial nerve (CN VII). Clinical relevance: Bell's palsy can occur due to inflammation or compression of the facial nerve at this site.

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Foramen Spinosum

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Structures: Middle meningeal artery and meningeal branch of mandibular nerve. Clinical relevance: The artery is often involved in epidural hematomas.

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Incisive Canal

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Structures: Nasopalatine nerve and sphenopalatine artery. Clinical relevance: May be a focal point for palatal pain syndromes.

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Foramen Magnum

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Structures: Spinal cord, vertebral arteries, and accessory nerves (CN XI). Clinical relevance: Herniation of cerebellar tonsils during increased intracranial pressure can be life-threatening.

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Hypoglossal Canal

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Structures: Hypoglossal nerve (CN XII). Clinical relevance: Hypoglossal nerve palsy can result in ipsilateral atrophy of the tongue muscles.

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Foramen Lacerum

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Structures: May transmit small meningeal arteries, occasionally the vidian nerve. Clinical relevance: Although largely filled with fibrocartilage, it can serve as a conduit for the spread of infections from the nasopharynx.

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Foramen Ovale

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Structures: Mandibular division of trigeminal nerve (CN V3), lesser petrosal nerve, accessory meningeal artery, emissary veins. Clinical relevance: Foramen ovale syndrome involves neuralgia of CN V3.

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Optic Canal

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Structures: Optic nerve (CN II) and ophthalmic artery. Clinical relevance: Fractures can lead to vision loss.

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Internal Acoustic Meatus

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Structures: Facial nerve (CN VII), vestibulocochlear nerve (CN VIII), labyrinthine artery. Clinical relevance: Acoustic neuromas can cause hearing loss and balance disorders.

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