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Involved in promoter clearance and transcription elongation as well as DNA repair

Transduces signals from cytokines and growth factors and regulates gene expression

Regulates the expression of genes that code for cytokines, cytokine receptors, and proteins involved in the growth and development of the immune system

Regulates gene expression in hematopoietic cells and is essential for the development of red blood cells and megakaryocytes

Regulates a variety of cellular processes including differentiation, proliferation, and apoptosis

Critical for the differentiation of T helper 17 cells, a subset of T helper cells involved in autoimmune diseases

Acts as a rapid-acting primary transcription factor, regulating the immune response

Involved in transcription of various genes, especially those related to the immune and stress responses

Responds to decreases in available oxygen in the cellular environment, or hypoxia, by activating the transcription of genes involved in energy metabolism, angiogenesis, and apoptosis

Recognizes and binds to the TATA box within the promoter

Functions as a tumor suppressor, regulating cell division by keeping cells from growing and dividing too fast or in an uncontrolled way

Plays a crucial role in the control of the cell cycle and action of tumor suppressor proteins, also involved in the regulation of apoptosis

Recognizes and binds to GC-rich motifs within the promoter regions of its target genes

Transcription factor that plays a pivotal role in the expression of the Th1 cytokine gene profile and the regulation of IFN-γ production