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Cushing's is often caused by overproduction of cortisol or prolonged use of corticosteroids, whereas Addison's is due to adrenal insufficiency.

Cushing's exhibits high cortisol levels, Addison's presents with low cortisol and often aldosterone levels.

Cushing's features weight gain, moon face, and buffalo hump; Addison's involves weight loss, fatigue, and hyperpigmentation.

Cushing's often results in hypertension, while Addison's can lead to hypotension.

Cushing's tends to have hypokalemia; Addison's disease generally presents with hyperkalemia.

Thinning of the skin and easy bruising are common in Cushing's, while Addison's can cause darkening of skin creases and scars.

Cushing's can cause mood swings, depression, and irritability; Addison's may be associated with depression and cognitive changes.

Cushing's may require surgery, radiation, or medication to lower cortisol; Addison's treatment involves hormone replacement.

Cushing's can lead to diabetes and dyslipidemia; Addison's can cause hypoglycemia and hyponatremia.

Cushing's diagnosis may include 24-hour urinary free cortisol test and dexamethasone suppression test; Addison's relies on ACTH stimulation test and serum electrolytes.

Cushing's syndrome is less common than Addison's disease in the general population.

Cushing's can lead to osteoporosis and increased fracture risk; bone complications in Addison's are less directly related.

Cushing's may cause adrenal hyperplasia or tumors, leading to enlargement; Addison's often involves adrenal atrophy or damage.

Cushing's can lead to hirsutism and menstrual irregularities in women; Addison's does not typically cause excess hair growth but can alter menstrual cycles.

Cushing's causes immunosuppression; Addison's does not directly suppress the immune system.