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Cushing's can lead to osteoporosis and increased fracture risk; bone complications in Addison's are less directly related.

Cushing's can lead to hirsutism and menstrual irregularities in women; Addison's does not typically cause excess hair growth but can alter menstrual cycles.

Cushing's often results in hypertension, while Addison's can lead to hypotension.

Cushing's may require surgery, radiation, or medication to lower cortisol; Addison's treatment involves hormone replacement.

Cushing's can lead to diabetes and dyslipidemia; Addison's can cause hypoglycemia and hyponatremia.

Cushing's syndrome is less common than Addison's disease in the general population.

Cushing's can cause mood swings, depression, and irritability; Addison's may be associated with depression and cognitive changes.

Thinning of the skin and easy bruising are common in Cushing's, while Addison's can cause darkening of skin creases and scars.

Cushing's may cause adrenal hyperplasia or tumors, leading to enlargement; Addison's often involves adrenal atrophy or damage.

Cushing's causes immunosuppression; Addison's does not directly suppress the immune system.

Patients with Cushing's can handle stress poorly due to excessive cortisol; Addison's patients may suffer from adrenal crisis under stress.

Cushing's is often caused by overproduction of cortisol or prolonged use of corticosteroids, whereas Addison's is due to adrenal insufficiency.

Cushing's tends to have hypokalemia; Addison's disease generally presents with hyperkalemia.

Cushing's exhibits high cortisol levels, Addison's presents with low cortisol and often aldosterone levels.

Cushing's features weight gain, moon face, and buffalo hump; Addison's involves weight loss, fatigue, and hyperpigmentation.