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Polycystic Ovary Syndrome (PCOS)

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Insulin Resistance

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A condition where cells fail to respond to insulin effectively, commonly found in PCOS, it leads to elevated insulin levels which can worsen hyperandrogenism and symptoms.

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Irregular Menstrual Cycles

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Inconsistent or prolonged menstrual intervals are a common feature of PCOS, likely due to imbalances in estrogen and progesterone, as well as increased androgen levels.

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Thinning Hair or Male-pattern Baldness

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Hair thinning on the scalp, commonly in a pattern observed in men, associated with elevated levels of androgens.

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Infertility

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Difficulties with ovulation due to hormonal imbalances, particularly the ratio of LH and FSH, contribute to infertility in women with PCOS.

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Weight Gain or Obesity

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Many women with PCOS have insulin resistance, leading to an increased risk of weight gain or obesity, often worsened by imbalanced levels of hormones such as insulin and leptin.

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Polycystic Ovaries

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Presence of multiple small cysts in the ovaries, detected by ultrasound, results from disrupted folliculogenesis due to hormonal imbalances including luteinizing hormone (LH) and follicle-stimulating hormone (FSH) ratios.

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Low Levels of Sex Hormone Binding Globulin (SHBG)

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Lower levels of SHBG in PCOS can lead to an increase in free androgen levels, exacerbating symptoms like hirsutism and acne.

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Sleep Apnea

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Higher incidence in women with PCOS, which may be influenced by high levels of androgens and insulin resistance, affecting sleep quality and breathing patterns.

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Increased Appetite or Hyperphagia

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Often associated with insulin resistance, leading to disruption in the regulation of satiety and hunger hormones such as leptin and ghrelin.

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High Levels of LH

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Elevated levels of luteinizing hormone relative to follicle-stimulating hormone are often seen in PCOS and can disrupt normal ovulation.

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Anxiety and Depression

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These psychological symptoms might be more common among women with PCOS, potentially linked to hormonal imbalances including elevated androgens and insulin resistance.

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Menstrual Cramping

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While not specific to PCOS, menstrual cramping may be exacerbated in women with the syndrome due to hormonal changes, particularly prostaglandin imbalances.

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Hirsutism

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Excessive hair growth on the face, chest, or back in women, mainly due to elevated androgen levels, such as testosterone.

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Acne or Oily Skin

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Increased androgen production can lead to overactive sebaceous glands, resulting in acne or oily skin.

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Acanthosis Nigricans

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Darkened patches of skin, indicative of insulin resistance, accompanied by hormonal changes that affect insulin signaling pathways.

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