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Growth Hormone Pathway
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GH-Binding Protein (GHBP)
Modulates GH availability to tissues and can extend the half-life of GH in blood.
Somatostatin (SS)
Inhibits the release of growth hormone, balancing the effects of GHRH and contributing to homeostasis.
Somatomedins
Group of proteins, including IGF-1, that are involved in stimulating cellular proliferation and inhibiting cellular death.
Growth Hormone (GH)
Stimulates growth in almost all tissues, increases protein synthesis, and promotes lipolysis and increased blood glucose.
IGF-1 Receptor (IGF1R)
Binds IGF-1, activating pathways that result in cell growth and survival.
GH Receptor (GHR)
Mediates the effects of GH, leading to growth and metabolic effects.
Insulin-like Growth Factor 1 (IGF-1)
Mediates many of the growth-promoting effects of GH, particularly in bone and cartilage cells.
Growth Hormone Releasing Hormone (GHRH)
Stimulates the release of growth hormone, thereby promoting body growth and increasing muscle mass.
Janus Kinase 2 (JAK2)
Associates with GHR upon GH binding and is activated, triggering downstream signaling pathways for growth.
Signal Transducer and Activator of Transcription (STAT)
Phosphorylated by JAK2, it dimerizes and translocates to the nucleus to impact gene expression and promote cell growth.
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