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Neuroendocrine Integration

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Regulation of Cortisol

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CRH from the hypothalamus triggers the release of ACTH from the pituitary, which in turn stimulates cortisol production from the adrenal cortex. Cortisol is involved in stress response.

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Regulation of Thyroid Function

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Hypothalamus and pituitary gland release TRH and TSH, respectively, to regulate the production of thyroid hormones T3 and T4, which control metabolism.

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Regulation of Growth Hormone

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GHRH stimulates the release of growth hormone (GH) from the pituitary, while somatostatin inhibits it. GH affects body growth and metabolism.

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Regulation of Water Balance

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The hypothalamus produces ADH (vasopressin) which acts on the kidneys to retain water and regulates blood osmolarity.

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Control of Reproductive Functions

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The hypothalamus releases GnRH, which stimulates the pituitary to produce LH and FSH, hormones involved in the reproductive cycle and gametogenesis.

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Hypothalamus-Pituitary Axis

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The central regulatory system that controls the release of hormones from the pituitary gland, influenced by hypothalamic hormones such as GnRH, TRH, CRH, GHRH, and somatostatin.

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Pineal Gland Function

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Responsible for the synthesis and secretion of melatonin, which is involved in regulating circadian rhythms.

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Sympathoadrenal System

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Involves the effects of the sympathetic nervous system and adrenal medulla in stress responses, releasing adrenaline and noradrenaline.

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Pancreatic Regulation of Blood Glucose

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The pancreas releases insulin and glucagon to regulate blood glucose levels; insulin decreases and glucagon increases blood glucose.

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Body Stress Response

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Activation of the HPA axis (hypothalamus-pituitary-adrenal axis) results in the release of CRH, ACTH, and cortisol, aiding the body in responding to stress.

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