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Neuroendocrine Integration
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Regulation of Cortisol
CRH from the hypothalamus triggers the release of ACTH from the pituitary, which in turn stimulates cortisol production from the adrenal cortex. Cortisol is involved in stress response.
Regulation of Thyroid Function
Hypothalamus and pituitary gland release TRH and TSH, respectively, to regulate the production of thyroid hormones T3 and T4, which control metabolism.
Regulation of Growth Hormone
GHRH stimulates the release of growth hormone (GH) from the pituitary, while somatostatin inhibits it. GH affects body growth and metabolism.
Regulation of Water Balance
The hypothalamus produces ADH (vasopressin) which acts on the kidneys to retain water and regulates blood osmolarity.
Control of Reproductive Functions
The hypothalamus releases GnRH, which stimulates the pituitary to produce LH and FSH, hormones involved in the reproductive cycle and gametogenesis.
Hypothalamus-Pituitary Axis
The central regulatory system that controls the release of hormones from the pituitary gland, influenced by hypothalamic hormones such as GnRH, TRH, CRH, GHRH, and somatostatin.
Pineal Gland Function
Responsible for the synthesis and secretion of melatonin, which is involved in regulating circadian rhythms.
Sympathoadrenal System
Involves the effects of the sympathetic nervous system and adrenal medulla in stress responses, releasing adrenaline and noradrenaline.
Pancreatic Regulation of Blood Glucose
The pancreas releases insulin and glucagon to regulate blood glucose levels; insulin decreases and glucagon increases blood glucose.
Body Stress Response
Activation of the HPA axis (hypothalamus-pituitary-adrenal axis) results in the release of CRH, ACTH, and cortisol, aiding the body in responding to stress.
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