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Hypopituitarism Causes and Effects

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Autoimmune Inflammation

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May cause lymphocytic hypophysitis, leading to varying degrees of pituitary hormone deficiencies, often during pregnancy or postpartum.

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Pituitary Tumor

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Reduced secretion of one or more pituitary hormones which can lead to symptoms like fatigue, weakness, and sexual dysfunction.

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Brain Surgery

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Could damage pituitary gland causing deficient hormone production, possibly leading to hormone replacement therapy.

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Ischemic or Hemorrhagic Stroke

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Can lead to pituitary infarction, resulting in hypopituitarism and potentially a medical emergency if adrenal insufficiency arises.

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Infections

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Severe infections, like meningitis, can affect the pituitary, leading to potential hormone deficiencies.

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Radiation Therapy

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Risk of impaired pituitary function, possibly causing deficiencies in growth hormone, ACTH, TSH, LH, and FSH over time.

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Genetic Disorders

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May lead to congenital defects in pituitary development, resulting in hypopituitarism evident from birth or early childhood.

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Empty Sella Syndrome

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May lead to reduced or absent hormone secretion due to the pituitary gland being compressed or flattened.

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Iron Overload Diseases (Hemochromatosis)

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Excessive iron deposition can lead to pituitary damage, causing hypopituitarism with symptoms like reduced libido and energy levels.

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Head Trauma

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Can cause decreased secretion of pituitary hormones, which may manifest as hormone deficiencies and related symptoms.

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