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Hypopituitarism Causes and Effects
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Autoimmune Inflammation
May cause lymphocytic hypophysitis, leading to varying degrees of pituitary hormone deficiencies, often during pregnancy or postpartum.
Pituitary Tumor
Reduced secretion of one or more pituitary hormones which can lead to symptoms like fatigue, weakness, and sexual dysfunction.
Brain Surgery
Could damage pituitary gland causing deficient hormone production, possibly leading to hormone replacement therapy.
Ischemic or Hemorrhagic Stroke
Can lead to pituitary infarction, resulting in hypopituitarism and potentially a medical emergency if adrenal insufficiency arises.
Infections
Severe infections, like meningitis, can affect the pituitary, leading to potential hormone deficiencies.
Radiation Therapy
Risk of impaired pituitary function, possibly causing deficiencies in growth hormone, ACTH, TSH, LH, and FSH over time.
Genetic Disorders
May lead to congenital defects in pituitary development, resulting in hypopituitarism evident from birth or early childhood.
Empty Sella Syndrome
May lead to reduced or absent hormone secretion due to the pituitary gland being compressed or flattened.
Iron Overload Diseases (Hemochromatosis)
Excessive iron deposition can lead to pituitary damage, causing hypopituitarism with symptoms like reduced libido and energy levels.
Head Trauma
Can cause decreased secretion of pituitary hormones, which may manifest as hormone deficiencies and related symptoms.
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