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Donors must be between the ages of 17 and 65 to donate blood, though some exceptions may apply with parental consent or in certain regions.

A minimum weight is required for safe donation, usually at least 110 pounds (50 kilograms), to ensure donor well-being and adequate blood volume.

Donors must be in good health and free from any cold, flu, or severe allergic symptoms on the day of donation.

Individuals engaging in high-risk behaviors may be deferred to protect recipient safety. This can include intravenous drug use or unprotected sex with multiple partners.

Recent travel may render someone temporarily ineligible due to the risk of infectious diseases, such as malaria, from certain regions.

A small blood test is done to ensure the donor has adequate iron levels to safely donate blood without risking anemia.

Potential donors taking certain medications or with chronic medical conditions may be temporarily or permanently deferred.

Blood pressure and pulse are measured to ensure they are within an acceptable range for donation to proceed safely.