Discover published sets by community

Mechanism: Genetic defect in glycoprotein Ib-V-IX complex on platelets; impairs adhesion. Symptoms: Bruising, nosebleeds, gum bleeding, menorrhagia. Treatment options: Platelet transfusions, antifibrinolytic agents, recombinant activated factor VII.

Mechanism: ADAMTS13 enzyme deficiency leads to large vWF-factor multimers and microthrombi. Symptoms: Microangiopathic hemolytic anemia, fever, kidney failure, neurological changes. Treatment options: Plasma exchange, corticosteroids, rituximab.

Mechanism: Genetic absence or dysfunction of glycoprotein IIb/IIIa on platelets precludes platelet aggregation. Symptoms: Mucocutaneous bleeding, epistaxis, menorrhagia. Treatment options: Platelet transfusions, antifibrinolytic agents, recombinant factor VIIa.

Mechanism: Autoimmune production of antibodies against platelets. Symptoms: Easy bruising, bleeding gums, petechiae. Treatment options: Corticosteroids, IV immunoglobulins, splenectomy if refractory.

Mechanism: Deficiency of clotting factor VIII. Symptoms: Joint bleeding, bruising, spontaneous bleeding. Treatment options: Factor VIII concentrate, desmopressin for mild cases, avoiding blood thinners.

Mechanism: Platelets express unusual receptor with increased affinity for von Willebrand factor. Symptoms: Similar to classic von Willebrand disease, including mucocutaneous bleeding. Treatment options: Care during surgeries, avoiding aspirin, antifibrinolytic medications.

Mechanism: Defective or deficient von Willebrand factor (vWF) which helps platelets clump and stick to blood vessel walls. Symptoms: Excessive bleeding from gums or nose, heavy menstrual periods, prolonged bleeding from cuts. Treatment options: Desmopressin, vWF-containing concentrates, antifibrinolytic agents.

Mechanism: Defective scrambling of phospholipids on the platelet surface, affects coagulation cascade. Symptoms: Mild bleeding tendency, wounds healing with delayed hemostasis. Treatment options: Supportive care, blood transfusions for severe bleeding.