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Bone Marrow Transplantation

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Engraftment Process

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The process by which transplanted stem cells start to grow and produce healthy blood cells in the bone marrow of the patient.

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Bone Marrow Transplant Rejection

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When the recipient's immune system attacks the transplanted marrow, considering it foreign.

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Stem Cell Sources for Transplant

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Stem cells for transplant can come from bone marrow, peripheral blood, or umbilical cord blood.

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Conditioning Regimen

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Pre-transplant process involving chemotherapy and/or radiation to prepare the patient for transplantation by killing cancer cells and suppressing the immune system.

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Types of Bone Marrow Transplants

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The main types are autologous (patient's own stem cells), allogeneic (donor stem cells), and syngeneic (stem cells from an identical twin).

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Bone Marrow Transplant Indications

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Used to treat various blood diseases such as leukemia, lymphoma, aplastic anemia, and some solid tumor cancers.

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Hematopoietic Stem Cell Transplantation (HSCT)

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A procedure that restores stem cells that have been destroyed by high doses of chemotherapy or radiation therapy.

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Complications: Graft-versus-Host Disease (GvHD)

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A condition where donor immune cells attack the patient's tissues; can be acute or chronic.

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Total Body Irradiation (TBI)

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A form of radiation therapy used as part of the conditioning regimen before a bone marrow transplant that targets the entire body.

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Matched Unrelated Donor (MUD) Transplants

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Allogeneic transplants where the donor is not related to the patient but is a close genetic match.

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