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Pediatric Immunology Basics
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Antibody
A protein produced by B cells that binds to antigens to neutralize them; antibodies in maternal milk provide passive immunity to newborns.
Innate Immunity
The non-specific first line of defense against pathogens present from birth, including physical barriers like the skin and mucous membranes.
Antigen
A substance that the immune system recognizes as foreign and responds to, which is particularly important in vaccine development for children.
Vaccination
The process of stimulating the immune system to develop immunity against a disease, often through the administration of vaccines in early childhood.
Immunization
The process by which an individual's immune system becomes fortified against an agent, typically through vaccination, essential in pediatric medicine to prevent disease.
Immunodeficiency
A state in which the immune system's ability to fight infectious disease is compromised or entirely absent, more critical to diagnose in early stages for children.
T cell
A lymphocyte that matures in the thymus and is critical for cell-mediated immunity, including the elimination of infected cells in children.
Adaptive Immunity
The specific immune response that develops over time and involves lymphocytes; includes features like immunological memory important for long-term protection in children.
Thymus
An organ located in the chest that produces T cells during early life, critical for the development of a child's immune system.
Leukocyte
A white blood cell that functions in the body's immune system by defending against infectious disease and foreign materials, crucial in monitoring pediatric health.
Passive Immunity
Immunity acquired by the transfer of antibodies or activated T cells from an immune host, such as through placental transfer to a fetus, important for newborn protection.
Lymphocyte
A type of white blood cell involved in the adaptive immune response and includes B and T cells, which are crucial for fighting infections in children.
Autoimmunity
A misdirected immune response in which the body attacks its own cells and tissues, with several autoimmune diseases presenting during childhood.
Immunoglobulin
Any of the class of proteins that function as antibodies, which play an important role in neonatal immunity acquired from maternal antibodies.
Active Immunity
Immunity that results from the production of antibodies by the person's own immune system after being exposed to an infectious agent, which can be stimulated by vaccines in children.
B cell
A lymphocyte that produces antibodies and plays a pivotal role in humoral immunity; B cell responses can be measured to assess vaccine efficacy in pediatric patients.
Anaphylaxis
A severe, potentially life-threatening allergic reaction that can occur in children to certain foods, medications, or insect stings, emphasizing the need for emergency care knowledge.
Hypersensitivity
An overreaction of the immune system to antigens that are usually harmless, such as in allergic reactions, which are common in pediatric patients.
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