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Historical treatments included mercury and guaiacum. The outcomes ranged from temporary remission to serious health complications and death.

Historical treatments included dietary supplementation with niacin. The outcomes were recovery if treated early; otherwise it could result in death.

Historical treatments included variolation and later vaccination. The outcome ultimately was the global eradication of the disease.

Historical treatments included oral hydration with salt and sugar solutions, often ineffectively. High mortality rates were common before the development of IV hydration.

Historical treatments included antitoxin and later antibiotics. Outcomes often resulted in death prior to the development of these treatments.

Historical treatments involved anti-inflammatory medication like salicylates and bed rest; outcomes prior to antibiotics included heart valve damage.

Historical treatments included sanatorium rest, pneumothorax, and phthisiotherapy. Outcomes varied with many succumbing to the disease before antibiotics.

Historical treatments included exposure to sunlight and dietary changes to include vitamin D rich foods. Outcomes could include recovery or permanent bone deformities.

Historical treatments included surgery, radium therapy, and later chemotherapy, but outcomes have historically been poor due to late detection.

Historically treated with isolation in leper colonies; Chaulmoogra oil was also used. Outcomes were social stigma and long-term disabilities.

Historical treatments included isolation and supportive care. Outcomes could be severe in infants and children without vaccination.

Historical treatments included dietary restrictions and herbal remedies. Colchicine was later used, improving outcomes.

Historical treatments included blood transfusions; outcomes were often fatal due to uncontrollable bleeding.

Historical treatments included draining lesions and supportive care; antibiotics later proved effective in improving outcomes.

Historical treatments were primarily supportive, including hydration. Antibiotics later provided more targeted outcomes.

Historical treatments included quinine derived from the cinchona tree. Outcomes varied prior to more effective antimalarial drugs.

Treatments were non-specific such as bloodletting and herbal remedies. The outcome was often death due to a lack of effective treatments.

Historical treatments were largely ineffective and included various topical applications; later, antibiotics improved outcomes.

Historical treatments involved iodine supplementation and surgery for large goiters. Outcomes have much improved with iodine fortification programs.

Treatments historically were supportive, focusing on managing symptoms. Outcomes included recovery or complications such as pneumonia or encephalitis.

Treatments were largely ineffective and included bloodletting, boil-lancing, and herbal remedies. The outcome was millions of deaths in Europe.

Historical treatments were dietary, involving the intake of fresh fruits rich in vitamin C. The outcomes were typically full recovery if treated early enough.

Historical treatments were largely supportive, including rest and hydration. The 1918 pandemic resulted in millions of deaths worldwide.

Historical treatments included quarantine and, later, antibiotics. Outcomes without antibiotics often resulted in complications or death.

Historical treatments were ineffective, often fatal once symptoms appeared; post-exposure vaccination has improved outcomes.

Treatments included the iron lung and physical therapy. The outcome for many was paralysis or death until the development of the vaccine.

Historical treatments included dietary replacement with thiamine. The outcome improved significantly with proper nutritional intake.

Historical treatments were mostly supportive, such as treating fever and dehydration. The outcome often was death, leading to high mortality during outbreaks.

Historical treatments involved sanitation and supportive care. Antibiotics later improved outcomes significantly.