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Chromatin Modifications
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CAR-modification of Histones
Involved in transcriptional activation and repression, associated with enhancer and promoter regions
Phosphorylation of Histones
Affects chromatin structure and transcription, often associated with chromosome condensation during mitosis
ADP-ribosylation of Histones
Can either activate or repress transcription; involved in DNA repair processes
Methylation of Histones
Can lead to either activation or repression of transcription, depending on the site of methylation
Acetylation of Histones
Increases transcriptional activity by relaxing chromatin structure
Ubiquitination of Histones
Can signal for either transcriptional activation or DNA repair depending on the context
Sumoylation of Histones
Usually represses transcription by promoting tighter chromatin structure
Demethylation of Histones
Can activate or repress transcription, depending on which methylated residues are affected
Citrullination of Histones
Leads to chromatin de-condensation and is associated with active transcription
Deacetylation of Histones
Leads to a tighter chromatin structure and reduced transcription
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