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Chromatin Modifications

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CAR-modification of Histones

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Involved in transcriptional activation and repression, associated with enhancer and promoter regions

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Phosphorylation of Histones

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Affects chromatin structure and transcription, often associated with chromosome condensation during mitosis

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ADP-ribosylation of Histones

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Can either activate or repress transcription; involved in DNA repair processes

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Methylation of Histones

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Can lead to either activation or repression of transcription, depending on the site of methylation

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Acetylation of Histones

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Increases transcriptional activity by relaxing chromatin structure

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Ubiquitination of Histones

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Can signal for either transcriptional activation or DNA repair depending on the context

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Sumoylation of Histones

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Usually represses transcription by promoting tighter chromatin structure

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Demethylation of Histones

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Can activate or repress transcription, depending on which methylated residues are affected

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Citrullination of Histones

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Leads to chromatin de-condensation and is associated with active transcription

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Deacetylation of Histones

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Leads to a tighter chromatin structure and reduced transcription

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