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Next-Generation Sequencing (NGS) Technologies
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Pacific Biosciences SMRT Sequencing
Principle: Single molecule real-time (SMRT) sequencing technology. Application: Known for long-read capabilities, useful for de novo genome assembly and detection of structural variants.
Ion Torrent Sequencing
Principle: Detects hydrogen ions released during DNA polymerization. Application: Suited for small genome sequencing and targeted sequencing.
10x Genomics Chromium
Principle: Utilizes microfluidics to partition cells or DNA, followed by barcoding for NGS. Application: Enables single-cell sequencing, CNV analysis and immune profiling amongst other complex genomic studies.
Illumina Sequencing
Principle: Uses reversible terminator technology for sequencing. Application: Widely used in genomics for variant detection and gene expression profiling.
Oxford Nanopore Sequencing
Principle: Measures change in electrical conductivity caused by DNA molecules passing through nanopores. Application: Portable sequencing and in-the-field analysis, especially useful for long reads and epigenetic modifications.
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