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Comparative Genomics Concepts

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Paralogs

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Genes related by duplication within a genome that have evolved new functions.

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Orthologs

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Genes in different species that evolved from a common ancestral gene by speciation.

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Functional Genomics

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The study of the relationship between genes and their function, often utilizing data across genomes.

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Pangenome

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The full complement of genes in a particular species, encompassing core and accessory genes.

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Phylogenetics

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The study of evolutionary relationships among biological entities, often species, individuals or genes.

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Copy-number Variation

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A form of structural variation in the genome where the number of copies of a particular gene varies between individuals in the population.

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Homology

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Refers to any similarity between characters that is due to their shared ancestry.

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Genomic Imprinting

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An epigenetic phenomenon that causes genes to be expressed in a parent-of-origin-specific manner.

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Molecular Clock Hypothesis

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A method used to determine time based on base-pair substitutions, which are assumed to occur at a constant rate among certain genes.

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Whole-Genome Duplication

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An event in which a genome or a segment of a genome has been copied or duplicated.

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Conservative and Nonconservative Substitutions

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Conservative substitutions are amino acid replacements that preserve the physicochemical properties of the original amino acid. Nonconservative substitutions refer to replacements that change these properties.

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Synteny

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The conservation of blocks of order within two sets of chromosomes that are being compared with each other.

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