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Combination of low-dose aspirin and heparin (usually low molecular weight heparin) to reduce the risk of miscarriage and other complications.

Thrombosis, which can occur in both arterial and venous systems, often leading to conditions such as deep venous thrombosis or stroke.

A mottled discoloration of the skin often seen in APS patients, believed to be due to microvascular thrombosis.

Autoantibodies targeted against phospholipid-binding proteins including lupus anticoagulant, anticardiolipin antibodies, and anti-beta-2 glycoprotein I.

An autoimmune disorder characterized by the presence of antiphospholipid antibodies causing thrombosis and/or pregnancy-related complications.

Requires one clinical (vascular thrombosis or pregnancy morbidity) and one laboratory (presence of antiphospholipid antibodies) criterion for diagnosis.

Recurrent miscarriages, which are often seen as a hallmark of APS in the obstetric population.

Long-term anticoagulation therapy is the mainstay treatment to prevent new thrombotic events, using vitamin K antagonists like warfarin or direct oral anticoagulants (DOACs).

Primary APS occurs in the absence of any other related disease, whereas Secondary APS is associated with another autoimmune disorder, commonly Systemic Lupus Erythematosus (SLE).

A rare, severe form of APS characterized by multiple organ thromboses and a high risk of morbidity and mortality, requiring aggressive anticoagulation and immunosuppression.

A common hematological finding in APS, usually mild and does not typically result in bleeding, despite low platelet counts.

Children can also be affected by APS, presenting similarly to adults with thrombosis and requiring similar management strategies.

Intravenous Immunoglobulin (IVIG) may be used in refractory APS, particularly in the setting of catastrophic APS or when anticoagulation alone is insufficient.

Used prophylactically in low-risk APS patients to reduce the likelihood of thrombotic events due to its antiplatelet effects.