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Selective xanthine oxidase inhibitor; used in chronic gout management, especially in patients intolerant to allopurinol.

Selectively inhibits JAK1; used in rheumatoid arthritis.

Inhibits T-cell activation by binding to CD80/86; used in rheumatoid arthritis.

Calcineurin inhibitor; used in rheumatoid arthritis and psoriasis.

Neutralize TNF-alpha, reducing inflammation; used in rheumatoid arthritis, ankylosing spondylitis, and psoriatic arthritis.

Inhibits pyrimidine synthesis; used in rheumatoid arthritis.

Janus kinase (JAK) inhibitor; used in rheumatoid arthritis, psoriatic arthritis, and ulcerative colitis.

Purine synthesis inhibitor, used in rheumatoid arthritis and systemic lupus erythematosus.

Inhibits B-lymphocyte stimulator protein; used in systemic lupus erythematosus.

JAK1 and JAK2 inhibitor; used off-label in rheumatology for myelofibrosis-related splenomegaly and constitutional symptoms.

COX-2 selective inhibitor; NSAID used for symptomatic relief in rheumatologic conditions, with a lower risk of gastrointestinal bleeding.

Inhibits inosine monophosphate dehydrogenase; used in lupus nephritis.

Inhibits IL-12 and IL-23; used in psoriatic arthritis.

NSAID; inhibits cyclooxygenase, used for symptomatic relief in various rheumatologic conditions including gout.

Inhibits IL-17A; used in psoriatic arthritis and ankylosing spondylitis.

Uricosuric agent that increases renal excretion of uric acid; used in gout management.

Recombinant uricase that converts uric acid to allantoin; used in refractory chronic gout.

Monoclonal antibody against IL-1 beta; used in gout flares and cryopyrin-associated periodic syndromes.

IL-1 receptor antagonist; used in rheumatoid arthritis and cryopyrin-associated periodic syndromes.

TNF-alpha inhibitor; used in rheumatoid arthritis, psoriatic arthritis, and ankylosing spondylitis.

IL-6 receptor antagonist; used in rheumatoid arthritis and Giant Cell Arteritis.

TNF-alpha inhibitor; used in rheumatoid arthritis, psoriatic arthritis, and ankylosing spondylitis.

Anti-inflammatory and immunomodulatory, used in rheumatoid arthritis and seronegative spondyloarthropathies.

Inhibits microtubule polymerization, used in gout prophylaxis and treatment.

Alkylating agent causing DNA cross-linking; used in vasculitis and severe lupus nephritis.

Depletes CD20+ B cells; used in rheumatoid arthritis and granulomatosis with polyangiitis.

PDE4 inhibitor, reducing inflammation by increasing intracellular cAMP; used in psoriatic arthritis.

NSAID; inhibits cyclooxygenase, used for symptomatic relief in various rheumatologic conditions.

Inhibits xanthine oxidase, used in chronic management of gout.

Chelating agent that binds copper, used in Wilson's disease and for features like swollen joints in rheumatoid arthritis.

JAK1 inhibitor; used in rheumatoid arthritis.

JAK inhibitor; used in rheumatoid arthritis.

Interferes with lysosomal activity and autophagy, used in rheumatoid arthritis and systemic lupus erythematosus.

Calcineurin inhibitor applied topically; used in dermatologic conditions associated with rheumatologic diseases.