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Inhibits dihydrofolate reductase, used in rheumatoid arthritis and psoriatic arthritis.

Interferes with lysosomal activity and autophagy, used in rheumatoid arthritis and systemic lupus erythematosus.

Anti-inflammatory and immunomodulatory, used in rheumatoid arthritis and seronegative spondyloarthropathies.

Inhibits pyrimidine synthesis; used in rheumatoid arthritis.

Purine synthesis inhibitor, used in rheumatoid arthritis and systemic lupus erythematosus.

Alkylating agent causing DNA cross-linking; used in vasculitis and severe lupus nephritis.

Calcineurin inhibitor; used in rheumatoid arthritis and psoriasis.

Inhibits inosine monophosphate dehydrogenase; used in lupus nephritis.

Neutralize TNF-alpha, reducing inflammation; used in rheumatoid arthritis, ankylosing spondylitis, and psoriatic arthritis.

Depletes CD20+ B cells; used in rheumatoid arthritis and granulomatosis with polyangiitis.

Inhibits T-cell activation by binding to CD80/86; used in rheumatoid arthritis.

IL-6 receptor antagonist; used in rheumatoid arthritis and Giant Cell Arteritis.

IL-1 receptor antagonist; used in rheumatoid arthritis and cryopyrin-associated periodic syndromes.

Inhibits IL-12 and IL-23; used in psoriatic arthritis.

Inhibits IL-17A; used in psoriatic arthritis and ankylosing spondylitis.

PDE4 inhibitor, reducing inflammation by increasing intracellular cAMP; used in psoriatic arthritis.

Inhibits B-lymphocyte stimulator protein; used in systemic lupus erythematosus.

Inhibits microtubule polymerization, used in gout prophylaxis and treatment.

Inhibits xanthine oxidase, used in chronic management of gout.

Selective xanthine oxidase inhibitor; used in chronic gout management, especially in patients intolerant to allopurinol.

Uricosuric agent that increases renal excretion of uric acid; used in gout management.

Recombinant uricase that converts uric acid to allantoin; used in refractory chronic gout.

Monoclonal antibody against IL-1 beta; used in gout flares and cryopyrin-associated periodic syndromes.

Chelating agent that binds copper, used in Wilson's disease and for features like swollen joints in rheumatoid arthritis.

Janus kinase (JAK) inhibitor; used in rheumatoid arthritis, psoriatic arthritis, and ulcerative colitis.

JAK inhibitor; used in rheumatoid arthritis.

Selectively inhibits JAK1; used in rheumatoid arthritis.

TNF-alpha inhibitor; used in rheumatoid arthritis, psoriatic arthritis, and ankylosing spondylitis.

TNF-alpha inhibitor; used in rheumatoid arthritis, psoriatic arthritis, and ankylosing spondylitis.

JAK1 and JAK2 inhibitor; used off-label in rheumatology for myelofibrosis-related splenomegaly and constitutional symptoms.

JAK1 inhibitor; used in rheumatoid arthritis.

Calcineurin inhibitor applied topically; used in dermatologic conditions associated with rheumatologic diseases.

NSAID; inhibits cyclooxygenase, used for symptomatic relief in various rheumatologic conditions.

NSAID; inhibits cyclooxygenase, used for symptomatic relief in various rheumatologic conditions including gout.