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Lupus Erythematosus Key Points
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SLE and Lung Involvement
Pleural effusion and pneumonitis are potential pulmonary manifestations of SLE.
Role of Antinuclear Antibodies (ANA)
ANA test is commonly positive in SLE patients and is often used as a screening tool.
Contraception and SLE
Women with SLE need careful selection of contraception to avoid hormonal influences that can contribute to flares.
Classic Lupus Rash
The malar rash, also known as the butterfly rash, is a classic skin manifestation of SLE.
Diagnostic Criteria for SLE
The ACR criteria include malar rash, discoid rash, photosensitivity, oral ulcers, arthritis, serositis, renal disorder, neurological disorder, hematological disorder, immunological disorder, and presence of antinuclear antibodies.
Neuropsychiatric SLE
Nervous system involvement in SLE can manifest as seizures, psychosis, and cognitive dysfunction.
Treatment of Lupus Skin Involvement
Topical corticosteroids and immunomodulators, as well as antimalarial drugs, can be used to treat lupus-related skin lesions.
Biologic Therapies for SLE
Biological agents, such as Belimumab, target specific components of the immune system to control SLE.
Role of Corticosteroids in SLE
Corticosteroids are used in SLE for their potent anti-inflammatory and immunosuppressive effects.
Flare Management in SLE
Flare management includes increasing medication doses, rest, and avoiding triggers such as sunlight.
Sun Exposure and SLE
Patients with SLE are advised to avoid sun exposure as it can worsen skin lesions and trigger flares.
Discoid Lupus Erythematosus
Discoid lupus is a chronic skin condition associated with SLE, characterized by disc-shaped, scaly, red patches.
Definition of Lupus (SLE)
Systemic Lupus Erythematosus (SLE) is an autoimmune disease where the immune system attacks healthy tissue.
Pharmacological Treatment for SLE
Treatment may include NSAIDs, corticosteroids, antimalarials, DMARDs, and biological agents.
Cardiovascular Risk in SLE
SLE increases the risk of cardiovascular diseases, hence monitoring and preventive strategies are important.
Hematological Manifestations in SLE
SLE can cause various blood disorders including anemia, leukopenia, thrombocytopenia, and antiphospholipid syndrome.
Sjogren's Syndrome and SLE
Sjogren's syndrome is a common overlap condition in SLE, characterized by dry eyes and dry mouth.
Common symptoms of SLE
Symptoms include fatigue, joint pain, rash, and fevers.
Pregnancy and SLE
SLE can affect pregnancy outcomes and requires close monitoring for both the mother and fetus.
Role of Anti-dsDNA Antibodies
Anti-dsDNA antibodies are more specific for SLE and correlate with disease activity.
Environmental Triggers of SLE
Environmental factors, such as UV light, infections, and stress, can trigger lupus flares.
Monitoring Disease Activity in SLE
Regular monitoring with blood tests, urine tests, and clinical assessments is necessary to assess disease activity and organ involvement in SLE.
Lupus Nephritis
Lupus nephritis is kidney inflammation caused by SLE and requires a renal biopsy for diagnosis.
First-line Drug for SLE
Hydroxychloroquine is often the first-line drug used for managing SLE due to its effectiveness and safety profile.
Complementary Therapies for SLE
Complementary approaches, such as diet modification, stress reduction, and physical therapy, can support medical treatment of SLE.
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