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Lupus Erythematosus Key Points

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SLE and Lung Involvement

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Pleural effusion and pneumonitis are potential pulmonary manifestations of SLE.

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Role of Antinuclear Antibodies (ANA)

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ANA test is commonly positive in SLE patients and is often used as a screening tool.

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Contraception and SLE

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Women with SLE need careful selection of contraception to avoid hormonal influences that can contribute to flares.

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Classic Lupus Rash

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The malar rash, also known as the butterfly rash, is a classic skin manifestation of SLE.

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Diagnostic Criteria for SLE

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The ACR criteria include malar rash, discoid rash, photosensitivity, oral ulcers, arthritis, serositis, renal disorder, neurological disorder, hematological disorder, immunological disorder, and presence of antinuclear antibodies.

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Neuropsychiatric SLE

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Nervous system involvement in SLE can manifest as seizures, psychosis, and cognitive dysfunction.

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Treatment of Lupus Skin Involvement

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Topical corticosteroids and immunomodulators, as well as antimalarial drugs, can be used to treat lupus-related skin lesions.

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Biologic Therapies for SLE

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Biological agents, such as Belimumab, target specific components of the immune system to control SLE.

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Role of Corticosteroids in SLE

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Corticosteroids are used in SLE for their potent anti-inflammatory and immunosuppressive effects.

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Flare Management in SLE

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Flare management includes increasing medication doses, rest, and avoiding triggers such as sunlight.

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Sun Exposure and SLE

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Patients with SLE are advised to avoid sun exposure as it can worsen skin lesions and trigger flares.

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Discoid Lupus Erythematosus

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Discoid lupus is a chronic skin condition associated with SLE, characterized by disc-shaped, scaly, red patches.

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Definition of Lupus (SLE)

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Systemic Lupus Erythematosus (SLE) is an autoimmune disease where the immune system attacks healthy tissue.

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Pharmacological Treatment for SLE

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Treatment may include NSAIDs, corticosteroids, antimalarials, DMARDs, and biological agents.

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Cardiovascular Risk in SLE

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SLE increases the risk of cardiovascular diseases, hence monitoring and preventive strategies are important.

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Hematological Manifestations in SLE

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SLE can cause various blood disorders including anemia, leukopenia, thrombocytopenia, and antiphospholipid syndrome.

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Sjogren's Syndrome and SLE

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Sjogren's syndrome is a common overlap condition in SLE, characterized by dry eyes and dry mouth.

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Common symptoms of SLE

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Symptoms include fatigue, joint pain, rash, and fevers.

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Pregnancy and SLE

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SLE can affect pregnancy outcomes and requires close monitoring for both the mother and fetus.

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Role of Anti-dsDNA Antibodies

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Anti-dsDNA antibodies are more specific for SLE and correlate with disease activity.

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Environmental Triggers of SLE

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Environmental factors, such as UV light, infections, and stress, can trigger lupus flares.

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Monitoring Disease Activity in SLE

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Regular monitoring with blood tests, urine tests, and clinical assessments is necessary to assess disease activity and organ involvement in SLE.

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Lupus Nephritis

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Lupus nephritis is kidney inflammation caused by SLE and requires a renal biopsy for diagnosis.

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First-line Drug for SLE

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Hydroxychloroquine is often the first-line drug used for managing SLE due to its effectiveness and safety profile.

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Complementary Therapies for SLE

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Complementary approaches, such as diet modification, stress reduction, and physical therapy, can support medical treatment of SLE.

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