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Antibiotic Mechanisms

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Nitrofurantoin

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Damages bacterial DNA, primarily used for urinary tract infections caused by Escherichia coli and Staphylococcus saprophyticus.

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Colistin

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Disrupts the outer cell membrane of Gram-negative bacteria by binding to lipopolysaccharide and phospholipids, used as a 'last-resort' antibiotic.

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Levofloxacin

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Inhibits DNA gyrase and topoisomerase IV, has a broad spectrum of activity including pseudomonas.

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Azithromycin

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Macrolide antibiotic that inhibits protein synthesis by binding to the 50S ribosomal subunit, used for respiratory infections, some STIs, and more.

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Isoniazid

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Inhibits the synthesis of mycolic acid in the mycobacterial cell wall, used specifically against Mycobacterium tuberculosis.

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Daptomycin

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Inserts into the bacterial cell membrane and causes rapid depolarization, leading to inhibition of protein, DNA, and RNA synthesis, used against Gram-positive bacteria.

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Erythromycin

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Macrolide that inhibits bacterial protein synthesis by binding to the 50S subunit, used for respiratory tract infections and more.

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Chloramphenicol

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Inhibits protein synthesis by binding to the 50S ribosomal subunit, broad-spectrum activity but used as a last resort due to toxicity.

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Fidaxomicin

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Inhibits RNA polymerase sigma subunit, targeting Clostridium difficile.

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Penicillin

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Inhibits bacterial cell wall synthesis, primarily targets Gram-positive bacteria.

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Tetracycline

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Inhibits protein synthesis by binding to the 30S subunit of the bacterial ribosome, used against a broad spectrum of bacteria.

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Ciprofloxacin

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Fluoroquinolone that inhibits DNA gyrase and topoisomerase IV, effective against Gram-negative and some Gram-positive bacteria.

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Clindamycin

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Inhibits protein synthesis by binding to the 50S ribosomal subunit, used mainly for anaerobic infections and Gram-positive cocci.

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Doxycycline

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Inhibits protein synthesis by binding to the 30S ribosomal subunit, effective against a variety of Gram-positive and Gram-negative bacteria.

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Amoxicillin

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Inhibits cell wall synthesis by binding to penicillin-binding proteins, used against Gram-positive and some Gram-negative bacteria.

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Cephalexin

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Inhibits cell wall synthesis, effective against Gram-positive cocci.

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Metronidazole

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Causes DNA strand breaks and loss of helical DNA structure, effective against anaerobic bacteria and protozoa.

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Vancomycin

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Inhibits cell wall synthesis by binding to the D-alanyl-D-alanine portion of cell wall precursors, targets MRSA and Gram-positive bacteria.

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Trimethoprim/Sulfamethoxazole (TMP/SMX)

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Inhibits folic acid synthesis pathway, effective against a broad spectrum of Gram-positive and Gram-negative organisms.

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Nystatin

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Binds to ergosterol, creating pores in the fungal cell membrane, primarily used for cutaneous, oral, or intestinal Candida infections.

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Linezolid

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Inhibits protein synthesis by binding to the 23S portion of the 50S subunit, used for Gram-positive infections including VRE and MRSA.

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Gentamicin

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Aminoglycoside that inhibits protein synthesis by binding to the 30S subunit, targets Gram-negative bacilli.

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Rifampin

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Inhibits DNA-dependent RNA polymerase, used for tuberculosis and as prophylaxis for meningococcus and Haemophilus influenzae type b.

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Fluconazole

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Inhibits fungal cytochrome P450 enzyme (14-alpha demethylase), reducing conversion of lanosterol to ergosterol, used for Candida infections and more.

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Amphotericin B

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Binds to ergosterol in fungal cell membranes causing increased membrane permeability and cell death, targets a wide range of fungi.

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