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Mechanism of action: Interferes with nuclear metabolism leading to inhibition of synthesis of DNA, RNA, phospholipids, and proteins. Targets Pneumocystis jirovecii and Trypanosoma species.

Mechanism of action: Disrupts mitochondrial membranes, inhibits cytochrome c oxidase, and induces apoptosis. Targets Leishmania species.

Mechanism of action: Reactive arsenical, binds to sulfhydryl groups in parasitic enzymes, disrupting metabolism. Targets Trypanosoma brucei (African trypanosomiasis).

Mechanism of action: Binds to parasitic enzymes and inhibits parasitic glycolysis and Krebs cycle. Targets Trypanosoma brucei (African trypanosomiasis).

Mechanism of action: Causes degenerative alterations in the intestinal cells, inhibits microtubule synthesis. Targets a broad range of helminths including nematodes and tapeworms.

Mechanism of action: Forms toxic free radicals which damage DNA. Targets protozoans like Trichomonas vaginalis and Giardia lamblia.

Mechanism of action: Interferes with the parasite's ability to metabolize and utilize erythrocyte hemoglobin. Targets Plasmodium species (malaria).

Mechanism of action: Increases invertebrate muscle cell membrane permeability to chloride ions with hyperpolarization and paralysis. Targets onchocerciasis and lymphatic filariasis.

Mechanism of action: Inhibits tubulin synthesis and glucose uptake, leading to death of adult worms. Targets hookworms, pinworms, and roundworms.

Mechanism of action: Inhibits dihydrofolate reductase, halting folic acid synthesis and therefore nucleic acid and protein synthesis. Targets Plasmodium species (malaria).

Mechanism of action: Generates toxic radicals, leading to a loss of essential parasite cellular functions. Targets Trypanosoma cruzi (Chagas disease).

Mechanism of action: Interferes with the pyruvate:ferredoxin oxidoreductase pathway, essential to anaerobic energy metabolism. Targets Cryptosporidium and Giardia.

Mechanism of action: Generates free radicals that damage parasite proteins and membranes. Targets Plasmodium species (malaria).

Mechanism of action: Increases membrane permeability to calcium in parasite, causing paralysis and death. Targets Schistosoma species and other flukes.