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Toxins and Enzymes
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Botulinum toxin
Causes muscular paralysis, Botox usage, potential bioweapon.
Tetanus toxin
Causes muscle spasms and lockjaw, can be fatal, preventable by vaccine.
Cholera toxin
Causes severe diarrhea, dehydration, and electrolyte loss; vaccine available.
Diphtheria toxin
Causes cell death, sore throat, and heart issues; preventable by vaccine.
Staphylococcal enterotoxin
Causes food poisoning, nausea, vomiting; heat-stable toxin.
Shiga toxin
Causes dysentery, hemolytic uremic syndrome (HUS); associated with E. coli O157:H7.
Alpha-toxin
Causes hemolysis, tissue necrosis, and gas gangrene; associated with Clostridium perfringens.
Pertussis toxin
Causes whooping cough symptoms, lymphocytosis, and sensitization to histamine.
Anthrax toxin
Causes respiratory failure, shock, can be used as a bioweapon; vaccine available.
Epsilon toxin
Causes edema, blood vessel permeability, and potentially fatal enterotoxemia.
Hyaluronidase
Facilitates bacterial spread in tissue by breaking down hyaluronic acid; 'spreading factor'.
Coagulase
Promotes blood clotting around bacterial cells, helping them evade the immune system.
Streptokinase
Dissolves blood clots, used to treat thrombosis; secreted by Streptococci.
Streptolysin O
Causes beta-hemolysis, immune system evasion; associated with Streptococcus pyogenes.
Pneumolysin
Contributes to pneumonia symptoms by damaging lung tissue; produced by Streptococcus pneumoniae.
Endotoxin (Lipopolysaccharide, LPS)
Triggers fever, shock, and often severe inflammation; structural component of Gram-negative bacteria.
Exotoxin A
Disrupts protein synthesis leading to cell death; associated with Pseudomonas aeruginosa infections.
Enterotoxin
Causes gastroenteritis symptoms by affecting the gastrointestinal system.
Verotoxin
Causes bloody diarrhea and can lead to hemolytic uremic syndrome (HUS); linked to E. coli O157:H7.
Neuraminidase
Helps pathogens access cells by cleaving terminal sialic acid residues; facilitates influenza virus release.
Lipase
Aids in digestion of lipids to promote nutrient acquisition and survival of bacteria within host.
Nucleases
Degradation of host nucleic acids facilitates bacterial infection and nutrient release.
Collagenase
Breaks down collagen in connective tissue, promoting bacterial spread; used medically to treat burns and ulcers.
Hemolysins
Destroys red blood cells to release hemoglobin; contributes to pathology of infections.
Proteases/Peptidases
Degrade host proteins for nutrient uptake or disrupt host tissues and immune responses.
Beta-lactamases
Confers bacterial resistance to beta-lactam antibiotics by breaking the antibiotic structure.
Cytolethal distending toxin (CDT)
Causes cellular distension, DNA damage, and can lead to cell cycle arrest; associated with some E. coli and Campylobacter species.
DNase
Destroys extracellular DNA in pus or at infection sites, diminishing host defense and aiding in spread.
Adenylate cyclase toxin
Increases cyclic AMP levels in host cells leading to altered cell functions and immune evasion; characteristic of Bordetella pertussis.
Leukocidins
Lyses leukocytes, impairs immune response, and contributes to the severity of infections such as pneumonia.
Enterotoxigenic E. coli (ETEC) heat-labile toxin (LT)
Causes traveler's diarrhea by stimulating fluid secretion in the intestines; structurally similar to cholera toxin.
Edema factor
Part of the anthrax toxin complex; increases fluid secretion, tissue swelling, and impairs immune responses.
Ricin
Inhibits protein synthesis causing cell death; highly toxic and can be used as a poison or bioweapon.
Listeriolysin O
Facilitates escape of Listeria monocytogenes from the phagosome within host cells, aiding in their spread.
Sulfhydryl-activated cytolysin
Damages tissues and cells; some are associated with severe infections like streptococcal toxic shock syndrome.
Thermostable direct hemolysin (TDH)
Causes cell lysis and is implicated in Vibrio parahaemolyticus-induced gastroenteritis.
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