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Toxins and Enzymes

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Lipase

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Aids in digestion of lipids to promote nutrient acquisition and survival of bacteria within host.

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Enterotoxigenic E. coli (ETEC) heat-labile toxin (LT)

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Causes traveler's diarrhea by stimulating fluid secretion in the intestines; structurally similar to cholera toxin.

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Tetanus toxin

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Causes muscle spasms and lockjaw, can be fatal, preventable by vaccine.

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Staphylococcal enterotoxin

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Causes food poisoning, nausea, vomiting; heat-stable toxin.

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Endotoxin (Lipopolysaccharide, LPS)

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Triggers fever, shock, and often severe inflammation; structural component of Gram-negative bacteria.

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Hyaluronidase

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Facilitates bacterial spread in tissue by breaking down hyaluronic acid; 'spreading factor'.

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Listeriolysin O

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Facilitates escape of Listeria monocytogenes from the phagosome within host cells, aiding in their spread.

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Sulfhydryl-activated cytolysin

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Damages tissues and cells; some are associated with severe infections like streptococcal toxic shock syndrome.

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Diphtheria toxin

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Causes cell death, sore throat, and heart issues; preventable by vaccine.

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Streptolysin O

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Causes beta-hemolysis, immune system evasion; associated with Streptococcus pyogenes.

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Coagulase

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Promotes blood clotting around bacterial cells, helping them evade the immune system.

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Adenylate cyclase toxin

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Increases cyclic AMP levels in host cells leading to altered cell functions and immune evasion; characteristic of Bordetella pertussis.

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Neuraminidase

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Helps pathogens access cells by cleaving terminal sialic acid residues; facilitates influenza virus release.

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Botulinum toxin

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Causes muscular paralysis, Botox usage, potential bioweapon.

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Shiga toxin

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Causes dysentery, hemolytic uremic syndrome (HUS); associated with E. coli O157:H7.

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Pertussis toxin

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Causes whooping cough symptoms, lymphocytosis, and sensitization to histamine.

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Collagenase

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Breaks down collagen in connective tissue, promoting bacterial spread; used medically to treat burns and ulcers.

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Thermostable direct hemolysin (TDH)

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Causes cell lysis and is implicated in Vibrio parahaemolyticus-induced gastroenteritis.

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Cholera toxin

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Causes severe diarrhea, dehydration, and electrolyte loss; vaccine available.

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Streptokinase

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Dissolves blood clots, used to treat thrombosis; secreted by Streptococci.

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Epsilon toxin

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Causes edema, blood vessel permeability, and potentially fatal enterotoxemia.

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Ricin

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Inhibits protein synthesis causing cell death; highly toxic and can be used as a poison or bioweapon.

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Anthrax toxin

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Causes respiratory failure, shock, can be used as a bioweapon; vaccine available.

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Exotoxin A

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Disrupts protein synthesis leading to cell death; associated with Pseudomonas aeruginosa infections.

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Leukocidins

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Lyses leukocytes, impairs immune response, and contributes to the severity of infections such as pneumonia.

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Verotoxin

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Causes bloody diarrhea and can lead to hemolytic uremic syndrome (HUS); linked to E. coli O157:H7.

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Nucleases

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Degradation of host nucleic acids facilitates bacterial infection and nutrient release.

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Alpha-toxin

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Causes hemolysis, tissue necrosis, and gas gangrene; associated with Clostridium perfringens.

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Beta-lactamases

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Confers bacterial resistance to beta-lactam antibiotics by breaking the antibiotic structure.

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Hemolysins

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Destroys red blood cells to release hemoglobin; contributes to pathology of infections.

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Pneumolysin

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Contributes to pneumonia symptoms by damaging lung tissue; produced by Streptococcus pneumoniae.

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Enterotoxin

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Causes gastroenteritis symptoms by affecting the gastrointestinal system.

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Proteases/Peptidases

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Degrade host proteins for nutrient uptake or disrupt host tissues and immune responses.

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Cytolethal distending toxin (CDT)

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Causes cellular distension, DNA damage, and can lead to cell cycle arrest; associated with some E. coli and Campylobacter species.

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DNase

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Destroys extracellular DNA in pus or at infection sites, diminishing host defense and aiding in spread.

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Edema factor

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Part of the anthrax toxin complex; increases fluid secretion, tissue swelling, and impairs immune responses.

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