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History of Neuroscience

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Introduction of the fMRI

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Functional magnetic resonance imaging (fMRI) allowed scientists to visualize brain activity, revolutionizing the study of cognition and brain disorders.

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Discovery of Neurons

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Discovered by Santiago Ramón y Cajal, neurons were identified as the basic unit of the nervous system. This led to the neuron doctrine which is fundamental to neuroscience.

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The Limbic System

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Paul MacLean's concept of the limbic system helped in the understanding of the neural bases of emotions, motivation, and behavior.

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Phrenology

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Although now discredited, phrenology suggested that brain function was localized, a concept partially true and influential in the development of neuroscience.

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LTP and Memory

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Long-term potentiation (LTP) discovery was key for understanding the cellular mechanisms underlying learning and memory.

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Default Mode Network

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The discovery of the default mode network advanced understanding of brain function during wakeful rest and its changes in various disorders.

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Phineas Gage's Accident

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Phineas Gage survived a severe brain injury that changed his personality, providing early evidence that specific brain areas are involved in certain functions.

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Neurogenesis in Adults

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The realization that neurogenesis occurs in the adult brain altered previous notions that all neurons are present at birth, impacting regenerative medicine.

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Wernicke's Area Discovery

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Carl Wernicke identified a brain region critical for language comprehension, emphasizing the complexity of language processing in the brain.

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Hebb's Rule

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Donald Hebb proposed the theory that 'neurons that fire together, wire together', which advanced the understanding of synaptic plasticity and learning.

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Discovery of the Reward System

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Research on the brain's reward system has elucidated mechanisms of addiction, decision-making, and motivation.

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Broca's Area Discovery

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Paul Broca discovered an area in the brain responsible for speech production, significant for understanding localization of brain function.

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Discovery of Synapses

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Charles Sherrington coined the term synapse for the junction between neurons, which is critical for understanding communication in the nervous system.

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Identification of Neurotransmitters

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Otto Loewi discovered the first neurotransmitter, acetylcholine, confirming that synapses communicate chemically.

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The Electroencephalogram (EEG)

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Hans Berger recorded the first human EEG, paving the way for studying electrical activity in the brain and neurological disorders like epilepsy.

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Split-brain Research

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Research on patients with severed corpus callosum revealed lateralization in the human brain and contributed to understanding of consciousness.

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CRISPR-Cas9 and Neuroscience

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The adaptation of CRISPR-Cas9 for editing genes has opened new avenues for understanding and potentially treating neurological disorders.

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Hodgkin-Huxley Model

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Alan Hodgkin and Andrew Huxley formulated a mathematical model to describe the initiation and propagation of action potentials in neurons.

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Mirror Neurons Discovery

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Discovery of mirror neurons provided insight into mechanisms of empathy and learning by imitation, playing a crucial role in social cognition.

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Optogenetics

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The development of optogenetics, allowing precise control of neuronal activity with light, has revolutionized the study of brain circuits.

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