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Cell Biology for Engineers
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Endoplasmic Reticulum (Smooth)
Lipid synthesis; detoxification; involves drug metabolism, implications in pharmacokinetics.
Mitochondria
Generates ATP through respiration; involved in cell death; pivotal in metabolic engineering and mitochondrial replacement therapy.
Lysosomes
Digests excess or worn-out organelles, food particles, and viruses or bacteria; model for targeted drug delivery and nanotechnology-based therapeutics.
Intermediate Filaments
Provide tensile strength; ensure integrity of the cell; relevant to understanding disease states and tissue engineering.
Cytoplasm
Location of metabolic processes; contains organelles; relevant to bioreactor design for tissue engineering.
Golgi Apparatus
Modifies, sorts, and packages proteins and lipids; important for designing delivery systems for drugs and biomolecules.
Centrosome
Organizes microtubules; roles in cell division; relevant to cancer research and targeted therapy.
Plasma Membrane
Protects cell from its surroundings; controls movement of substances in and out; key in tissue engineering and bio-sensing devices.
Endoplasmic Reticulum (Rough)
Synthesis of membrane and secretory proteins; folding and quality control; significant in production of recombinant proteins.
Nucleus
Stores genetic material (DNA); directs cell activities; development of personalized medicine and gene therapy.
Microtubules
Support the cell; guide organelle movement; crucial in drug targeting and nanodevice design, like for cancer therapy.
Microfilaments (Actin filaments)
Facilitate cell movement; muscle contraction; key in designing synthetic tissues and muscle repair technologies.
Ribosomes
Synthesizes proteins; potential targets for antibiotics; important for protein-based therapeutics manufacturing.
Peroxisomes
Breaks down fatty acids and detoxifies harmful substances; role in metabolic engineering and disease mechanisms for treatments.
Cytoskeleton
Provides structural support and shape; involves cell movement; used in understanding and developing biomaterials for structural integrity.
Cell Adhesion Molecules
Mediate binding of cell to cell or cell to ECM; important for tissue engineering and wound healing applications.
Desmosomes
Provide mechanical strength to tissues; involved in cellular adhesion studies for tissue engineering.
Gap Junctions
Allow for communication between cells; crucial for the development of artificial tissues and understanding cardiac dysfunctions.
Tight Junctions
Forms a barrier to prevent leakage of extracellular fluid; critical for designing bio-barriers and drug delivery systems.
Extracellular Matrix (ECM)
Provides structural and biochemical support; core to the understanding of tissue engineering and regenerative medicine.
Cell Division (Mitosis)
Process by which a cell divides to produce two daughter cells; basis for tissue growth and repair; crucial in cancer treatment strategies.
Cell Signaling
Process by which cells respond to external stimuli; central in drug design and precision medicine for cell-specific targets.
Pinocytosis
Cell drinking process; internalizes fluid; applied to nanoparticle uptake studies and drug delivery mechanisms.
DNA Replication
Copies genetic material; critical for cell division; essential in gene cloning and therapy.
Apoptosis
Programmed cell death; removes cells that are no longer needed; targeted for therapies in cancer and autoimmune diseases.
Necrosis
Uncontrolled cell death; often results from injury; used to understand tissue damage mechanisms and inflammatory responses.
Electrochemical Gradient
Driving force behind the movement of ions; critical in neural signaling and cardiac function; key to biosensor functionality.
Phagocytosis
Cell eating process; engulfing of particles; strategic for developing targeted drug delivery and immunotherapies.
Transcription
DNA to RNA; enables protein synthesis; gene expression manipulation for therapeutic proteins production.
Osmosis
Water movement across selective membrane; vital for maintaining cell turgor; principles applied in designing dialysis machines and medical implants.
Translation
RNA to Protein; decoding of mRNA; applied to develop cell-free protein synthesis systems for pharmaceutical productions.
Proteostasis
Maintenance of cellular protein levels; relevant in drug discovery for neurodegenerative diseases.
Cell Division (Meiosis)
Results in four haploid cells; genetic variability; fundamental to reproductive technology and understanding of hereditary diseases.
Passive Transport
Movement of substances across membrane without energy; principles utilized in drug formulation and passive prosthetic osmosis.
Ion Channels
Facilitate ion movement across the membrane; key to neural function; targets for treatments of channelopathies.
Receptor-Mediated Endocytosis
Cells ingest extracellular molecules; crucial for drug delivery systems and targeted therapy designs.
Autophagy
Degradation of cell's own components; cellular quality control; implications in neurodegenerative diseases and aging.
Active Transport
Substances moved against gradient using ATP; important for maintaining cell environments; mimicked in bioengineering designs for controllable drug release.
Stem Cells
Cells with the potential to develop into many different cell types; critical in therapeutic cloning and regenerative medicine.
Photosynthesis
Conversion of light energy to chemical energy; essential for oxygen production; exploited in bioremediation applications.
Cancer
Uncontrolled cell division; leads to tumors; important for biomedical engineers in developing diagnostics and treatments.
Protein Folding
Process by which proteins achieve their functional 3D structure; crucial for biologics manufacturing and in understanding misfolding diseases.
Cellular Respiration
Production of ATP from nutrients; vital for cell energy; leveraged in metabolic engineering for biosynthesis of products.
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