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Cell Biology for Engineers

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Endoplasmic Reticulum (Smooth)

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Lipid synthesis; detoxification; involves drug metabolism, implications in pharmacokinetics.

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Mitochondria

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Generates ATP through respiration; involved in cell death; pivotal in metabolic engineering and mitochondrial replacement therapy.

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Lysosomes

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Digests excess or worn-out organelles, food particles, and viruses or bacteria; model for targeted drug delivery and nanotechnology-based therapeutics.

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Intermediate Filaments

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Provide tensile strength; ensure integrity of the cell; relevant to understanding disease states and tissue engineering.

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Cytoplasm

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Location of metabolic processes; contains organelles; relevant to bioreactor design for tissue engineering.

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Golgi Apparatus

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Modifies, sorts, and packages proteins and lipids; important for designing delivery systems for drugs and biomolecules.

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Centrosome

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Organizes microtubules; roles in cell division; relevant to cancer research and targeted therapy.

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Plasma Membrane

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Protects cell from its surroundings; controls movement of substances in and out; key in tissue engineering and bio-sensing devices.

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Endoplasmic Reticulum (Rough)

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Synthesis of membrane and secretory proteins; folding and quality control; significant in production of recombinant proteins.

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Nucleus

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Stores genetic material (DNA); directs cell activities; development of personalized medicine and gene therapy.

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Microtubules

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Support the cell; guide organelle movement; crucial in drug targeting and nanodevice design, like for cancer therapy.

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Microfilaments (Actin filaments)

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Facilitate cell movement; muscle contraction; key in designing synthetic tissues and muscle repair technologies.

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Ribosomes

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Synthesizes proteins; potential targets for antibiotics; important for protein-based therapeutics manufacturing.

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Peroxisomes

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Breaks down fatty acids and detoxifies harmful substances; role in metabolic engineering and disease mechanisms for treatments.

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Cytoskeleton

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Provides structural support and shape; involves cell movement; used in understanding and developing biomaterials for structural integrity.

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Cell Adhesion Molecules

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Mediate binding of cell to cell or cell to ECM; important for tissue engineering and wound healing applications.

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Desmosomes

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Provide mechanical strength to tissues; involved in cellular adhesion studies for tissue engineering.

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Gap Junctions

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Allow for communication between cells; crucial for the development of artificial tissues and understanding cardiac dysfunctions.

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Tight Junctions

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Forms a barrier to prevent leakage of extracellular fluid; critical for designing bio-barriers and drug delivery systems.

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Extracellular Matrix (ECM)

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Provides structural and biochemical support; core to the understanding of tissue engineering and regenerative medicine.

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Cell Division (Mitosis)

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Process by which a cell divides to produce two daughter cells; basis for tissue growth and repair; crucial in cancer treatment strategies.

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Cell Signaling

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Process by which cells respond to external stimuli; central in drug design and precision medicine for cell-specific targets.

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Pinocytosis

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Cell drinking process; internalizes fluid; applied to nanoparticle uptake studies and drug delivery mechanisms.

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DNA Replication

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Copies genetic material; critical for cell division; essential in gene cloning and therapy.

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Apoptosis

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Programmed cell death; removes cells that are no longer needed; targeted for therapies in cancer and autoimmune diseases.

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Necrosis

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Uncontrolled cell death; often results from injury; used to understand tissue damage mechanisms and inflammatory responses.

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Electrochemical Gradient

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Driving force behind the movement of ions; critical in neural signaling and cardiac function; key to biosensor functionality.

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Phagocytosis

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Cell eating process; engulfing of particles; strategic for developing targeted drug delivery and immunotherapies.

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Transcription

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DNA to RNA; enables protein synthesis; gene expression manipulation for therapeutic proteins production.

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Osmosis

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Water movement across selective membrane; vital for maintaining cell turgor; principles applied in designing dialysis machines and medical implants.

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Translation

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RNA to Protein; decoding of mRNA; applied to develop cell-free protein synthesis systems for pharmaceutical productions.

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Proteostasis

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Maintenance of cellular protein levels; relevant in drug discovery for neurodegenerative diseases.

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Cell Division (Meiosis)

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Results in four haploid cells; genetic variability; fundamental to reproductive technology and understanding of hereditary diseases.

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Passive Transport

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Movement of substances across membrane without energy; principles utilized in drug formulation and passive prosthetic osmosis.

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Ion Channels

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Facilitate ion movement across the membrane; key to neural function; targets for treatments of channelopathies.

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Receptor-Mediated Endocytosis

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Cells ingest extracellular molecules; crucial for drug delivery systems and targeted therapy designs.

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Autophagy

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Degradation of cell's own components; cellular quality control; implications in neurodegenerative diseases and aging.

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Active Transport

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Substances moved against gradient using ATP; important for maintaining cell environments; mimicked in bioengineering designs for controllable drug release.

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Stem Cells

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Cells with the potential to develop into many different cell types; critical in therapeutic cloning and regenerative medicine.

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Photosynthesis

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Conversion of light energy to chemical energy; essential for oxygen production; exploited in bioremediation applications.

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Cancer

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Uncontrolled cell division; leads to tumors; important for biomedical engineers in developing diagnostics and treatments.

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Protein Folding

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Process by which proteins achieve their functional 3D structure; crucial for biologics manufacturing and in understanding misfolding diseases.

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Cellular Respiration

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Production of ATP from nutrients; vital for cell energy; leveraged in metabolic engineering for biosynthesis of products.

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