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Drug Delivery Systems

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Intravenous Delivery Systems

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Mechanism of action: Drug is administered directly into the bloodstream, offering immediate effect. Usage: Commonly used in hospitals for rapid drug effects and when high specificity is required.

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Rectal Delivery Systems

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Mechanism of action: Drugs are absorbed through the rectal mucosa. Usage: Useful for drugs that cause nausea or vomit when taken orally, or when oral administration is not possible.

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Ionic Exchange Resins

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Mechanism of action: Implements resins that can release drug ions in exchange for ions from body fluids. Usage: Commonly used in oral delivery to prolong and control the drug release rate.

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Oral Delivery Systems

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Mechanism of action: Utilizes the gastrointestinal tract for absorption of the drug into the bloodstream. Usage: Most common form for self-administration of pharmaceuticals.

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Osmotic Pumps

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Mechanism of action: A drug reservoir system that uses osmosis to achieve a controlled release of medication. Usage: Used for treating chronic conditions, such as diabetes and hypertension, with consistent dose requirements.

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Monoclonal Antibodies

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Mechanism of action: Monoclonal antibodies bind to specific antigens, marking them for immune system attack or blocking their action. Usage: Used in cancer treatment, autoimmune diseases, and transplant rejections.

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Inhalation Delivery Systems

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Mechanism of action: Delivers drugs directly to the lungs for rapid absorption into the bloodstream. Usage: Primarily used for respiratory conditions like asthma or COPD.

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Intramuscular Delivery Systems

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Mechanism of action: Drugs are injected into muscles, allowing for slower absorption than intravenous injection. Usage: Useful for vaccines and medications requiring slower release.

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Controlled Release Systems

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Mechanism of action: Drugs are released over time through various mechanisms such as diffusion, degradation, or swelling of the delivery matrix. Usage: Enhances patient compliance by reducing frequency of dosing.

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Implantable Delivery Systems

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Mechanism of action: Implants placed within the body that release drugs over an extended period. Usage: Used for long-term treatments such as hormone replacement therapies and chronic pain management.

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Vaccine Adjuvants

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Mechanism of action: Substances that enhance the body's immune response to an antigen. Usage: Used to improve efficacy of vaccines, allowing for a stronger and longer-lasting immune response.

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Pulsatile Drug Delivery Systems

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Mechanism of action: Designed to release drugs in pulses instead of a steady release, mimicking the body's natural rhythms. Usage: Ideal for drugs where constant dosing is not ideal, such as hormones in chronotherapy.

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Intranasal Delivery Systems

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Mechanism of action: Drugs are administered through the nasal cavity for systemic or local effects. Usage: Employed for peptide drugs like desmopressin, as well as for vaccinations.

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Hydrogels

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Mechanism of action: Three-dimensional polymeric networks that can swell in water and release drugs at a controlled rate. Usage: Ideal for wound dressings and drug delivery in tissue engineering.

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Magnetic Drug Targeting

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Mechanism of action: Utilizes magnetic particles to direct and concentrate the drug to a specific area within the body. Usage: Being researched for use in targeting chemotherapy to reduce systemic side effects.

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Polymeric Micelles

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Mechanism of action: Utilizes self-assembling block copolymers forming nanoscale structures for drug encapsulation. Usage: Used to improve water solubility of hydrophobic drugs and in drug targeting.

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Subcutaneous Delivery Systems

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Mechanism of action: Drugs are injected into the layer of skin directly below the dermis. Usage: Provides a slow, continuous release of medication, used for insulin and hormones.

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Liposomal Delivery Systems

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Mechanism of action: Utilizes lipid-based vesicles to encapsulate drugs, improving stability and targeting specific cells. Usage: Commonly used in cancer treatments to reduce side-effects of chemotherapy.

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Nanoparticle Delivery Systems

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Mechanism of action: Uses particles on the nanometer scale to deliver drugs and improve cellular uptake. Usage: Used to improve the solubility and bio-distribution of drugs, especially in targeted cancer therapies.

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Targeted Delivery Systems

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Mechanism of action: Drugs are directed to specific sites of action, reducing systemic distribution and side-effects. Usage: Primarily used in cancer therapy to target tumor cells with minimal impact on healthy cells.

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Buccal/Sublingual Delivery Systems

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Mechanism of action: Drugs are absorbed directly into the bloodstream via the mucous membranes of the mouth. Usage: Used for drugs that require rapid onset without GI tract involvement.

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Ocular Delivery Systems

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Mechanism of action: Drugs are administered to the eye for local treatment of ocular conditions. Usage: Used primarily for treating glaucoma, infections, and inflammation of the eye.

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Microneedle Delivery Systems

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Mechanism of action: Uses arrays of tiny needles to deliver drugs through the outer layer of skin without reaching the pain receptors. Usage: Offers a less invasive alternative to injections and can improve patient compliance.

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Dissolvable Films

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Mechanism of action: Thin films that contain a dose of medication, dissolving when in contact with a moist surface. Usage: Used for local drug delivery in the oral cavity or as transdermal patches.

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Transdermal Delivery Systems

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Mechanism of action: Delivers drugs through the skin directly into the bloodstream, bypassing the gastrointestinal tract. Usage: Used for drugs that require steady, controlled release over time.

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Gene Therapy Delivery Systems

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Mechanism of action: Delivers genetic material into cells to compensate for abnormal genes or to produce a beneficial protein. Usage: Used to treat genetic disorders, cancers, and some viral infections.

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Bioadhesive Delivery Systems

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Mechanism of action: Uses materials that can adhere to biological tissues allowing prolonged drug action at the site of application. Usage: Common in oral and ocular drug delivery for extended contact time.

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Photodynamic Therapy

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Mechanism of action: Uses light-sensitive drugs activated by specific wavelengths of light to destroy cancer cells. Usage: Used to treat certain types of cancer and precancerous conditions.

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Microencapsulation

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Mechanism of action: Drug particles are encased in a biodegradable material to protect the drug from degradation and control release. Usage: Used to extend the drug's presence in the body and reduce dosing frequency.

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Mucoadhesive Delivery Systems

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Mechanism of action: Drug delivery systems that adhere to the mucous membrane to enhance drug absorption and increase retention time. Usage: Useful in nasal and oral drug delivery systems.

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